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Tbio
GNL3
Guanine nucleotide-binding protein-like 3

Protein Summary
Description
May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity). The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394799
  • ENSP00000378278
  • ENSG00000163938
  • ENST00000418458
  • ENSP00000395772

Symbol
  • E2IG3
  • NS
  • NS
  • E2IG3
  • NNP47
  • C77032
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
disease perturbation
0.99
virus perturbation
0.99
molecular function
0.95
interacting protein
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.75   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 451   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.75   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 451   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (355)
ZNF317
Tdark
Family:  TF
Novelty:  1.58030176
p_int:  0.995056514
p_ni:  0.004808441
p_wrong:  0.000135045
Data Source:  BioPlex
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.993089032
p_ni:  0.006910721
p_wrong:  2.48e-7
Data Source:  BioPlex
ZNF121
Tdark
Family:  TF
Novelty:  0.233609
p_int:  0.98783298
p_ni:  0.012100622
p_wrong:  0.000066397
Data Source:  BioPlex
MRPS30
Tbio
Novelty:  0.08115544
p_int:  0.974827564
p_ni:  0.025172436
Data Source:  BioPlex
MRPL32
Tdark
Novelty:  0.58976136
p_int:  0.974442855
p_ni:  0.02544563
p_wrong:  0.000111515
Score:  0.238
Data Source:  BioPlex,STRINGDB
RPL36AL
Tbio
Novelty:  0.09336423
p_int:  0.97301647
p_ni:  0.026978104
p_wrong:  0.000005426
Score:  0.242
Data Source:  BioPlex,STRINGDB
MRPL9
Tdark
Novelty:  0.43920695
p_int:  0.965194859
p_ni:  0.034805141
Score:  0.213
Data Source:  BioPlex,STRINGDB
NLE1
Tbio
Novelty:  0.03831535
p_int:  0.958443574
p_ni:  0.04151377
p_wrong:  0.000042655
Score:  0.961
Data Source:  BioPlex,STRINGDB
MRPL15
Tdark
Novelty:  4.68753354
p_int:  0.956965489
p_ni:  0.043034511
Score:  0.38
Data Source:  BioPlex,STRINGDB
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.949947944
p_ni:  0.049905376
p_wrong:  0.00014668
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
9
8
21
97.4
BMI-adjusted waist circumference
4
8
13
92.2
waist circumference
2
5
5
90.8
waist-hip ratio
2
6
7
90.8
red blood cell distribution width
2
2
2
86.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
21
97.4
BMI-adjusted waist circumference
13
92.2
waist circumference
5
90.8
waist-hip ratio
7
90.8
red blood cell distribution width
2
86.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein nucleolar 3
VGNC:8837
460431
Macaque
G protein nucleolar 3
695877
Mouse
MGI:1353651
30877
Rat
RGD:631354
290556
Dog
G protein nucleolar 3
VGNC:41327
100685258
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein nucleolar 3
Macaque
G protein nucleolar 3
Mouse
Rat
Dog
G protein nucleolar 3
Publication Statistics
PubMed Score 120.75
PubMed score by year
PubTator Score 87.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title