Tbio GNL2 Nucleolar GTP-binding protein 2

Protein Summary

Description

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195).

Uniprot Accession IDs

• Q13823
• Q9BWN7

Gene Name

• GNL2

Ensembl ID

• ENST00000373062
• ENSP00000362153
• ENSG00000134697

Symbol

• NGP1
• NGP1
• Nog2
• Nug2
• Ngp-1
• HUMAUANTIG

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
kinase perturbation	0.88
protein domain	0.85
virus perturbation	0.85
interacting protein	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.08   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.08   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0