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Tbio
GNG13
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, retinal, and neuronal tissues and plays a key role in taste transduction (Li et al., 2006 [PubMed 16473877]).[supplied by OMIM, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248150
  • ENSP00000248150
  • ENSG00000127588

Symbol
  • h2-35
  • G(gamma)13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.68
kinase perturbation
0.66
PubMedID
0.59
cell type or tissue
0.56
transcription factor
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.04   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.04   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (938)
GNB3
Tbio
Novelty:  0.0037117
Score:  0.999
Data Source:  Reactome,STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.999
Data Source:  STRINGDB
GNB4
Tbio
Novelty:  0.08250797
Score:  0.999
Data Source:  STRINGDB
GNAT3
Tbio
Novelty:  0.00702357
Score:  0.974
Data Source:  Reactome,STRINGDB
GNG3
Tbio
Novelty:  0.16941216
Score:  0.971
Data Source:  STRINGDB
GNAO1
Tbio
Novelty:  0.00315097
Score:  0.97
Data Source:  STRINGDB
GNB2
Tbio
Novelty:  0.08682553
Score:  0.966
Data Source:  STRINGDB
GNB5
Tbio
Novelty:  0.0067714
Score:  0.962
Data Source:  STRINGDB
GNG12
Tbio
Novelty:  0.12611933
Score:  0.962
Data Source:  STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
Score:  0.961
Data Source:  STRINGDB
Nearest Tclin Targets (29)
Explore Nearest Tclin Targets
1 – 5 of 16
CHRM1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
F2R
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CHRM2
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CNR1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
GABBR2
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  3
Pathways (85)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

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Find Similar Targets
Items per page:
1 – 5 of 54
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of kainate receptors upon glutamate binding
Reactome
Adrenaline,noradrenaline inhibits insulin secretion
Reactome
Aquaporin-mediated transport
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of kainate receptors upon glutamate binding
Adrenaline,noradrenaline inhibits insulin secretion
Aquaporin-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer antigen 125 measurement
1
3
3
83.5
BMI-adjusted hip circumference
2
5
6
81.3
appendicular lean mass
2
2
2
76.8
BMI-adjusted waist circumference
1
6
6
73.4
mean corpuscular volume
1
1
1
65
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer antigen 125 measurement
3
83.5
BMI-adjusted hip circumference
6
81.3
appendicular lean mass
2
76.8
BMI-adjusted waist circumference
6
73.4
mean corpuscular volume
1
65
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
G protein subunit gamma 13
722398
Mouse
MGI:1925616
64337
Rat
RGD:1593806
685451
Dog
G protein subunit gamma 13
VGNC:41319
611349
Horse
G protein subunit gamma 13
VGNC:18430
100065327
Species
Name
OMA
EggNOG
Inparanoid
Macaque
G protein subunit gamma 13
Mouse
Rat
Dog
G protein subunit gamma 13
Horse
G protein subunit gamma 13
Publication Statistics
PubMed Score 13.04
PubMed score by year
PubTator Score 5.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title