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Tbio
GNB5
Guanine nucleotide-binding protein subunit beta-5

Protein Summary
Description
Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (PubMed:27677260). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity). Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal tran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261837
  • ENSP00000261837
  • ENSG00000069966
  • ENST00000358784
  • ENSP00000351635
  • ENST00000396335
  • ENSP00000379626

Symbol
  • GB5
  • IDDCA
  • LADCI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
protein domain
0.92
transcription factor perturbation
0.84
pathway
0.77
microRNA
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.92   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.92   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (598)
RGS6
Tbio
Novelty:  0.02200804
p_int:  0.999999971
p_ni:  2.4e-8
p_wrong:  5e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
RGS7
Tbio
Novelty:  0.01643407
p_int:  0.999998375
p_ni:  5.08e-7
p_wrong:  0.000001117
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RGS9
Tbio
Novelty:  0.06662559
p_int:  0.999995945
p_ni:  0.000004055
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
GNG2
Tbio
Novelty:  0.04807242
p_int:  0.999991378
p_ni:  0.000008622
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
PRPF40B
Tdark
Novelty:  0.04278291
p_int:  0.999973653
p_ni:  0.000026337
p_wrong:  1e-8
Score:  0.825
Data Source:  BioPlex,STRINGDB
PDCL
Tbio
Novelty:  0.00317454
p_int:  0.999950183
p_ni:  0.000049817
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.891809865
p_ni:  0.108190135
Score:  0.919
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.879036925
p_ni:  0.120963075
Score:  0.91
Data Source:  BioPlex,STRINGDB
COPS5
Tchem
Novelty:  0.00406225
p_int:  0.877340394
p_ni:  0.122659606
Data Source:  BioPlex
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.791071591
p_ni:  0.208928409
Score:  0.93
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (26)
Explore Nearest Tclin Targets
1 – 5 of 16
F2R
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CHRM2
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CHRM1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CNR1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
GABBR1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
Pathways (121)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 53
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of kainate receptors upon glutamate binding
Reactome
Adrenaline,noradrenaline inhibits insulin secretion
Reactome
Aquaporin-mediated transport
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of kainate receptors upon glutamate binding
Adrenaline,noradrenaline inhibits insulin secretion
Aquaporin-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
46.1
HbA1c measurement
1
1
1
31.4
heel bone mineral density
1
1
1
8.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
46.1
HbA1c measurement
1
31.4
heel bone mineral density
1
8.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:101848
14697
Rat
RGD:620759
83579
Dog
G protein subunit beta 5
VGNC:41316
608623
Horse
G protein subunit beta 5
VGNC:51526
100146498
Cow
G protein subunit beta 5
VGNC:29462
535365
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
G protein subunit beta 5
Horse
G protein subunit beta 5
Cow
G protein subunit beta 5
Publication Statistics
PubMed Score 155.92
PubMed score by year
PubTator Score 51.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title