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Tbio
GNB4
Guanine nucleotide-binding protein subunit beta-4

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000232564
  • ENSP00000232564
  • ENSG00000114450
  • ENST00000468623
  • ENSP00000419693

Symbol
  • CMTD1F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
protein domain
0.92
transcription factor perturbation
0.91
microRNA
0.86
pathway
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.36   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.36   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (587)
GNG2
Tbio
Novelty:  0.04807242
p_int:  0.999999216
p_ni:  7.84e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
GNGT1
Tbio
Novelty:  0.05291961
p_int:  0.999996337
p_ni:  0.000003663
Score:  0.999
Data Source:  BioPlex,STRINGDB
GNG3
Tbio
Novelty:  0.16941216
p_int:  0.999960626
p_ni:  0.000039372
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
P63092
Tbio
Novelty:  0.00284739
p_int:  0.999727486
p_ni:  0.000272514
Score:  0.964
Data Source:  BioPlex,Reactome,STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
p_int:  0.999654373
p_ni:  0.000345627
Score:  0.991
Data Source:  BioPlex,STRINGDB
GNG4
Tbio
Novelty:  0.14371438
p_int:  0.998619542
p_ni:  0.00122695
p_wrong:  0.000153508
Score:  0.999
Data Source:  BioPlex,STRINGDB
GNAI3
Tbio
Novelty:  0.03484857
p_int:  0.998493831
p_ni:  0.001506168
p_wrong:  1e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
p_int:  0.994298471
p_ni:  0.005701222
p_wrong:  3.07e-7
Score:  0.989
Data Source:  BioPlex,STRINGDB
GNA13
Tbio
Novelty:  0.04149138
p_int:  0.98437158
p_ni:  0.01562842
Score:  0.957
Data Source:  BioPlex,STRINGDB
GALK2
Tbio
Family:  Kinase
Novelty:  0.06382824
p_int:  0.943481139
p_ni:  0.056518561
p_wrong:  2.99e-7
Score:  0.231
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (26)
Explore Nearest Tclin Targets
1 – 5 of 16
F2R
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CHRM1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CHRM2
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CNR1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
GABBR1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
Pathways (102)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 51
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of kainate receptors upon glutamate binding
Reactome
Adrenaline,noradrenaline inhibits insulin secretion
Reactome
Aquaporin-mediated transport
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of kainate receptors upon glutamate binding
Adrenaline,noradrenaline inhibits insulin secretion
Aquaporin-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
54.4
2
3
0
1.1
46.8
platelet crit
1
1
1
29
heart rate
1
1
1
17.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
54.4
0
1.1
46.8
platelet crit
1
29
heart rate
1
17.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit beta 4
VGNC:8836
460862
Macaque
G protein subunit beta 4
709489
Mouse
MGI:104581
14696
Rat
RGD:1359321
294962
Dog
G protein subunit beta 4
VGNC:41315
488087
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit beta 4
Macaque
G protein subunit beta 4
Mouse
Rat
Dog
G protein subunit beta 4
Publication Statistics
PubMed Score 15.36
PubMed score by year
PubTator Score 7.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title