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Tbio
GNB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative sp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229264
  • ENSP00000229264
  • ENSG00000111664

Symbol
  • CSNB1H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
biological term
0.95
protein domain
0.92
pathway
0.7
disease
0.67


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.56   (req: < 5)
Gene RIFs: 223   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.56   (req: >= 5)
Gene RIFs: 223   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (622)
GNGT1
Tbio
Novelty:  0.05291961
p_int:  0.999997482
p_ni:  0.000001791
p_wrong:  7.27e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
GNG2
Tbio
Novelty:  0.04807242
p_int:  0.99982248
p_ni:  3.48e-7
p_wrong:  0.000177172
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
p_int:  0.999139884
p_ni:  0.000651863
p_wrong:  0.000208252
Score:  0.969
Data Source:  BioPlex,STRINGDB
SLC36A3
Tdark
Family:  Transporter
Novelty:  0.04150102
p_int:  0.939096936
p_ni:  0.030008718
p_wrong:  0.030894346
Score:  0.685
Data Source:  BioPlex,STRINGDB
ZNF131
Tbio
Family:  TF
Novelty:  0.18894578
p_int:  0.939096936
p_ni:  0.030008718
p_wrong:  0.030894346
Score:  0.316
Data Source:  BioPlex,STRINGDB
RCAN2
Tbio
Novelty:  0.00174006
p_int:  0.861386497
p_ni:  0.133400711
p_wrong:  0.005212793
Score:  0.187
Data Source:  BioPlex,STRINGDB
THAP3
Tdark
Family:  TF
Novelty:  0.52942342
p_int:  0.832047705
p_ni:  0.131188067
p_wrong:  0.036764228
Data Source:  BioPlex
CDH26
Tbio
Novelty:  0.11829125
p_int:  0.773865726
p_ni:  0.16988463
p_wrong:  0.056249645
Data Source:  BioPlex
CXCL13
Tbio
Novelty:  0.00118688
p_int:  0.768706683
p_ni:  0.209813816
p_wrong:  0.021479501
Score:  0.9
Data Source:  BioPlex,STRINGDB
GNG12
Tbio
Novelty:  0.12611933
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets (29)
Explore Nearest Tclin Targets
1 – 5 of 16
CHRM2
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CHRM1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
F2R
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CNR1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
GABBR2
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  3
Pathways (135)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 62
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Activation of kainate receptors upon glutamate binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Activation of kainate receptors upon glutamate binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
2
9
86.1
refractive error measurement
2
1
1
7.8
82.4
age at onset
1
1
0
7.8
63.4
Myopia
3
1
0
1.3
63.4
ganglion cell inner plexiform layer thickness measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
9
86.1
refractive error measurement
1
7.8
82.4
age at onset
0
7.8
63.4
Myopia
0
1.3
63.4
ganglion cell inner plexiform layer thickness measurement
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit beta 3
VGNC:8413
100612078
Macaque
G protein subunit beta 3
713913
Mouse
MGI:95785
14695
Rat
RGD:708344
60449
Dog
G protein subunit beta 3
VGNC:41314
403511
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit beta 3
Macaque
G protein subunit beta 3
Mouse
Rat
Dog
G protein subunit beta 3
Publication Statistics
PubMed Score 281.56
PubMed score by year
PubTator Score 359.67
PubTator score by year
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Related Publications
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PMID
Year
Title