You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GNB1L
Guanine nucleotide-binding protein subunit beta-like protein 1

Protein Summary
Description
This gene encodes a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 6 WD repeats and is highly expressed in the heart. The gene maps to the region on chromosome 22q11, which is deleted in DiGeorge syndrome, trisomic in derivative 22 syndrome and tetrasomic in cat-eye syndrome. Therefore, this gene may contribute to the etiology of those disorders. Transcripts from this gene share exons with some transcripts from the C22orf29 gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329517
  • ENSP00000331313
  • ENSG00000185838
  • ENST00000403325
  • ENSP00000385154
  • ENST00000405009
  • ENSP00000384626

Symbol
  • GY2
  • KIAA1645
  • WDR14
  • GY2
  • FKSG1
  • WDR14
  • WDVCF
  • DGCRK3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
transcription factor binding site profile
0.81
interacting protein
0.77
small molecule perturbation
0.76
histone modification site profile
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.19   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.19   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
GAS2L1
Tbio
Novelty:  0.17484834
p_int:  0.997106137
p_ni:  0.002893848
p_wrong:  1.5e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.994047308
p_ni:  0.005952691
p_wrong:  1e-9
Data Source:  BioPlex
MT1F
Tbio
Novelty:  0.03838808
p_int:  0.990193951
p_ni:  0.0098058
p_wrong:  2.49e-7
Score:  0.181
Data Source:  BioPlex,STRINGDB
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.988171173
p_ni:  0.011828827
Data Source:  BioPlex
TEKT2
Tbio
Novelty:  0.04607893
p_int:  0.984189987
p_ni:  0.015810013
Score:  0.157
Data Source:  BioPlex,STRINGDB
ASPRV1
Tbio
Family:  Enzyme
Novelty:  0.0278626
p_int:  0.97917298
p_ni:  0.02082646
p_wrong:  5.6e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
CNPY2
Tbio
Novelty:  0.090889
p_int:  0.977611578
p_ni:  0.022388422
Score:  0.19
Data Source:  BioPlex,STRINGDB
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.965894912
p_ni:  0.034105067
p_wrong:  2.1e-8
Score:  0.295
Data Source:  BioPlex,STRINGDB
KCNJ5
Tchem
Family:  IC
Novelty:  0.00385775
p_int:  0.964425761
p_ni:  0.035574239
Score:  0.175
Data Source:  BioPlex,STRINGDB
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.961886527
p_ni:  0.038113473
Score:  0.181
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
5
5
95.2
platelet count
6
4
6
84.2
3
2
0
1.2
83.4
mean platelet volume
3
1
3
77.5
susceptibility to childhood ear infection measurement
1
1
0
1.1
75.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
95.2
platelet count
6
84.2
0
1.2
83.4
mean platelet volume
3
77.5
susceptibility to childhood ear infection measurement
0
1.1
75.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit beta 1 like
VGNC:12878
104003675
Mouse
MGI:1338057
13972
Rat
RGD:1594165
680266
Dog
G protein subunit beta 1 like
VGNC:41312
486418
Horse
G protein subunit beta 1 like
VGNC:18424
100052160
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit beta 1 like
Mouse
Rat
Dog
G protein subunit beta 1 like
Horse
G protein subunit beta 1 like
Publication Statistics
PubMed Score 238.19
PubMed score by year
PubTator Score 36.35
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title