Tbio GNAZ Guanine nucleotide-binding protein G(z) subunit alpha

Protein Summary

Description

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P19086
• B2R6C1
• Q4QRJ6

Gene Name

• GNAZ

Ensembl ID

• ENST00000615612
• ENSP00000478892
• ENSG00000128266

Symbol

• gz-alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
gene perturbation	0.86
cellular component	0.81
cell type or tissue	0.79
histone modification site profile	0.76

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Heterotrimeric G-protein / Guanine Nucleotide-binding Protein G(z) Subunit Alpha

DTO Classes

Protein / Enzyme Modulator / G-protein / Heterotrimeric G-protein / Guanine Nucleotide-binding Protein G(z) Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.94   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 314   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.94   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0