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Tbio
GNAT2
Guanine nucleotide-binding protein G(t) subunit alpha-2

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351050
  • ENSP00000251337
  • ENSG00000134183

Symbol
  • GNATC
  • ACHM4
  • GNATC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
gene perturbation
0.66
cellular component
0.65
cell line
0.59
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.67   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.67   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (138)
GNAI3
Tbio
Novelty:  0.03484857
p_int:  0.999998882
p_ni:  0.000001032
p_wrong:  8.7e-8
Score:  0.915
Data Source:  BioPlex,STRINGDB
GNG3
Tbio
Novelty:  0.16941216
p_int:  0.99999761
p_ni:  0.000002387
p_wrong:  3e-9
Score:  0.96
Data Source:  BioPlex,STRINGDB
GPSM3
Tbio
Novelty:  0.01632501
p_int:  0.997543085
p_ni:  0.00000524
p_wrong:  0.002451675
Data Source:  BioPlex
ACSL4
Tbio
Family:  Enzyme
Novelty:  0.0072645
p_int:  0.95896454
p_ni:  0.04103546
Score:  0.229
Data Source:  BioPlex,STRINGDB
OCIAD1
Tbio
Novelty:  0.05701069
p_int:  0.942819474
p_ni:  0.057180525
Score:  0.188
Data Source:  BioPlex,STRINGDB
SNX5
Tbio
Novelty:  0.04075649
p_int:  0.921982022
p_ni:  0.078017976
p_wrong:  2e-9
Data Source:  BioPlex
UNC119
Tchem
Novelty:  0.00396292
p_int:  0.862562762
p_ni:  0.137437235
p_wrong:  3e-9
Score:  0.34
Data Source:  BioPlex,STRINGDB
ACSL3
Tbio
Family:  Enzyme
Novelty:  0.01772336
p_int:  0.772980184
p_ni:  0.227019816
Score:  0.544
Data Source:  BioPlex,STRINGDB
CNGB3
Tchem
Family:  IC
Novelty:  0.01174942
Score:  0.997
Data Source:  STRINGDB
RHO
Tbio
Family:  GPCR
Novelty:  0.00012925
Score:  0.99
Data Source:  Reactome,STRINGDB
Pathways (20)
Beta-catenin independent WNT signaling (R-HSA-3858494)

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1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Ca2+ pathway
Chaperonin-mediated protein folding
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
G alpha (i) signalling events
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
11
11
98.3
low density lipoprotein cholesterol measurement
2
7
8
96.3
body mass index
12
3
22
94.4
total cholesterol measurement
1
4
4
91.2
apolipoprotein A 1 measurement
1
1
1
85.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
11
98.3
low density lipoprotein cholesterol measurement
8
96.3
body mass index
22
94.4
total cholesterol measurement
4
91.2
apolipoprotein A 1 measurement
1
85.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha transducin 2
VGNC:8331
469402
Macaque
G protein subunit alpha transducin 2
699442
Mouse
MGI:95779
14686
Rat
RGD:1309514
365901
Dog
G protein subunit alpha transducin 2
VGNC:41308
490119
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha transducin 2
Macaque
G protein subunit alpha transducin 2
Mouse
Rat
Dog
G protein subunit alpha transducin 2
Publication Statistics
PubMed Score 54.67
PubMed score by year
PubTator Score 26.27
PubTator score by year
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Related Publications
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PMID
Year
Title