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Tbio
GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286548
  • ENSP00000286548
  • ENSG00000156052

Symbol
  • GAQ
  • GAQ
  • SWS
  • CMC1
  • G-ALPHA-q
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
virus perturbation
1
kinase perturbation
0.96
transcription factor perturbation
0.96
pathway
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1060.23   (req: < 5)
Gene RIFs: 158   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1060.23   (req: >= 5)
Gene RIFs: 158   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (421)
GNG3
Tbio
Novelty:  0.16941216
p_int:  0.999981091
p_ni:  0.000018909
Score:  0.964
Data Source:  BioPlex,STRINGDB
GNGT1
Tbio
Novelty:  0.05291961
p_int:  0.999974957
p_ni:  0.000025043
Score:  0.955
Data Source:  BioPlex,STRINGDB
GNG2
Tbio
Novelty:  0.04807242
p_int:  0.999966856
p_ni:  0.000033144
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
RIC8A
Tbio
Novelty:  0.01846696
p_int:  0.999896106
p_ni:  0.000103894
Score:  0.832
Data Source:  BioPlex,STRINGDB
GJB7
Tbio
Novelty:  0.12555147
p_int:  0.994708253
p_ni:  0.005291735
p_wrong:  1.2e-8
Data Source:  BioPlex
GNG4
Tbio
Novelty:  0.14371438
p_int:  0.994573176
p_ni:  0.005426824
Score:  0.958
Data Source:  BioPlex,STRINGDB
DUSP22
Tbio
Family:  Enzyme
Novelty:  0.01579003
p_int:  0.992963483
p_ni:  0.00703648
p_wrong:  3.6e-8
Data Source:  BioPlex
ATG3
Tbio
Novelty:  0.00541077
p_int:  0.984858431
p_ni:  0.015141543
p_wrong:  2.6e-8
Score:  0.151
Data Source:  BioPlex,STRINGDB
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.97808976
p_ni:  0.021909359
p_wrong:  8.81e-7
Data Source:  BioPlex
S1PR1
Tclin
Family:  GPCR
Novelty:  0.00162513
p_int:  0.970897618
p_ni:  0.029102364
p_wrong:  1.8e-8
Data Source:  BioPlex
Nearest Tclin Targets (47)
Explore Nearest Tclin Targets
Pathways (104)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

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Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
Acetylcholine regulates insulin secretion
Reactome
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Reactome
Free fatty acids regulate insulin secretion
Reactome
G alpha (q) signalling events
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
Acetylcholine regulates insulin secretion
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Free fatty acids regulate insulin secretion
G alpha (q) signalling events
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
33.1
vitamin D measurement
1
1
1
4.3
electrocardiography
1
1
2
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
33.1
vitamin D measurement
1
4.3
electrocardiography
2
0.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha q
VGNC:13886
472962
Mouse
MGI:95776
14682
Rat
RGD:620770
81666
Dog
G protein subunit alpha q
VGNC:41306
403928
Horse
G protein subunit alpha q
VGNC:18419
100063136
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha q
Mouse
Rat
Dog
G protein subunit alpha q
Horse
G protein subunit alpha q
Publication Statistics
PubMed Score 1060.23
PubMed score by year
PubTator Score 289.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title