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Tbio
GNAL
Guanine nucleotide-binding protein G(olf) subunit alpha

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters. This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269162
  • ENSP00000269162
  • ENSG00000141404
  • ENST00000334049
  • ENSP00000334051
  • ENST00000423027
  • ENSP00000408489
  • ENST00000535121
  • ENSP00000439023
  • ENST00000602628
  • ENSP00000473600

Symbol
  • DYT25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor
0.76
interacting protein
0.7
transcription factor binding site profile
0.67
tissue sample
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.34   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.34   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (523)
P63092
Tbio
Novelty:  0.00284739
p_int:  1
Score:  0.967
Data Source:  BioPlex,STRINGDB
MAGED2
Tbio
Novelty:  0.0134998
p_int:  0.999976863
p_ni:  0.000023137
Score:  0.858
Data Source:  BioPlex,STRINGDB
FNDC5
Tbio
Novelty:  0.0015827
p_int:  0.961046272
p_ni:  0.009009477
p_wrong:  0.029944252
Score:  0.206
Data Source:  BioPlex,STRINGDB
CHIA
Tchem
Family:  Enzyme
Novelty:  0.00181726
p_int:  0.9528813
p_ni:  0.006099116
p_wrong:  0.041019584
Score:  0.228
Data Source:  BioPlex,STRINGDB
GNG2
Tbio
Novelty:  0.04807242
Score:  0.98
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.972
Data Source:  Reactome,STRINGDB
ADCY3
Tbio
Family:  Enzyme
Novelty:  0.00260265
Score:  0.971
Data Source:  STRINGDB
ADCY8
Tchem
Family:  Enzyme
Novelty:  0.00510386
Score:  0.968
Data Source:  STRINGDB
O95467
Tbio
Novelty:  0.00284739
Score:  0.967
Data Source:  STRINGDB
P84996
Tbio
Novelty:  0.00284739
Score:  0.967
Data Source:  STRINGDB
Nearest Tclin Targets (12)
Explore Nearest Tclin Targets
1 – 5 of 12
ADORA2A
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
HRH2
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
CHRM5
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
ADRB3
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
Pathways (71)
Activation of GABAB receptors (R-HSA-991365)

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Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of GABAB receptors
Reactome
Adenylate cyclase activating pathway
Reactome
Adenylate cyclase inhibitory pathway
Reactome
G alpha (i) signalling events
Reactome
G alpha (s) signalling events
Name
Explore in Pharos
Explore in Source
Activation of GABAB receptors
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
G alpha (i) signalling events
G alpha (s) signalling events
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
6.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha L
VGNC:13263
455285
Mouse
MGI:95774
14680
Rat
RGD:2715
24611
Dog
G protein subunit alpha L
VGNC:41304
607658
Horse
G protein subunit alpha L
VGNC:18417
100050622
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha L
Mouse
Rat
Dog
G protein subunit alpha L
Horse
G protein subunit alpha L
Publication Statistics
PubMed Score 57.34
PubMed score by year
PubTator Score 39.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title