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Tbio
GNAI3
Guanine nucleotide-binding protein G(k) subunit alpha

Protein Summary
Description
Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K(+) channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369851
  • ENSP00000358867
  • ENSG00000065135

Symbol
  • 87U6
  • ARCND1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
molecular function
0.99
pathway
0.89
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.27   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.27   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (432)
GNAI1
Tbio
Novelty:  0.0488971
p_int:  0.999999997
p_ni:  3e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
RGS12
Tbio
Novelty:  0.02857864
p_int:  0.999999992
p_ni:  3e-9
p_wrong:  4e-9
Score:  0.98
Data Source:  BioPlex,STRINGDB
GNAO1
Tbio
Novelty:  0.00315097
p_int:  0.999999749
p_ni:  2.5e-7
Score:  0.938
Data Source:  BioPlex,STRINGDB
GNG4
Tbio
Novelty:  0.14371438
p_int:  0.999999514
p_ni:  4.86e-7
Score:  0.983
Data Source:  BioPlex,STRINGDB
RGS14
Tbio
Novelty:  0.01986201
p_int:  0.999999215
p_ni:  2.38e-7
p_wrong:  5.46e-7
Score:  0.996
Data Source:  BioPlex,STRINGDB
GPSM1
Tbio
Novelty:  0.03510582
p_int:  0.999999175
p_ni:  7.97e-7
p_wrong:  2.7e-8
Score:  0.984
Data Source:  BioPlex,STRINGDB
GNAT2
Tbio
Novelty:  0.01683655
p_int:  0.999998882
p_ni:  0.000001032
p_wrong:  8.7e-8
Score:  0.915
Data Source:  BioPlex,STRINGDB
ANKRD13B
Tdark
Novelty:  1.45055536
p_int:  0.99999845
p_ni:  4e-9
p_wrong:  0.000001546
Score:  0.316
Data Source:  BioPlex,STRINGDB
RAP1GAP
Tbio
Family:  Enzyme
Novelty:  0.0111232
p_int:  0.99999641
p_ni:  2.5e-8
p_wrong:  0.000003565
Score:  0.529
Data Source:  BioPlex,STRINGDB
GNB2
Tbio
Novelty:  0.08682553
p_int:  0.999979578
p_ni:  0.000020422
Score:  0.99
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (48)
Explore Nearest Tclin Targets
Pathways (104)
ADP signalling through P2Y purinoceptor 12 (R-HSA-392170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of GABAB receptors
Reactome
Adenylate cyclase inhibitory pathway
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 12
Activation of GABAB receptors
Adenylate cyclase inhibitory pathway
Chaperonin-mediated protein folding
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (38)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (52)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
14
4
24
98.7
apolipoprotein B measurement
2
12
12
95.5
glomerular filtration rate
4
4
4
95.4
self reported educational attainment
4
4
3
6.3
94.3
low density lipoprotein cholesterol measurement
4
10
12
94.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
24
98.7
apolipoprotein B measurement
12
95.5
glomerular filtration rate
4
95.4
self reported educational attainment
3
6.3
94.3
low density lipoprotein cholesterol measurement
12
94.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha i3
VGNC:8327
457093
Macaque
G protein subunit alpha i3
699310
Mouse
MGI:95773
14679
Rat
RGD:2714
25643
Dog
G protein subunit alpha i3
VGNC:41303
611810
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha i3
Macaque
G protein subunit alpha i3
Mouse
Rat
Dog
G protein subunit alpha i3
Publication Statistics
PubMed Score 34.27
PubMed score by year
PubTator Score 42.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title