Tbio GNAI1 Guanine nucleotide-binding protein G(i) subunit alpha-1

Protein Summary

Description

Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• P63096
• A8KA88
• B4E2V1
• C9J3A4
• P04898
• P11015
• P31871
• Q5U074
• Q8TAN5
• Q9UGA4

Gene Name

• GNAI1

Ensembl ID

• ENST00000351004
• ENSP00000343027
• ENSG00000127955
• ENST00000442586
• ENSP00000391439
• ENST00000457358
• ENSP00000410572
• ENST00000648098
• ENSP00000497717
• ENST00000648306
• ENSP00000497773
• ENST00000648412
• ENSP00000497051
• ENST00000648476
• ENSP00000497179
• ENST00000648663
• ENSP00000497379
• ENST00000648832
• ENSP00000497765
• ENST00000648877
• ENSP00000497760
• ENST00000648953
• ENSP00000496800
• ENST00000649225
• ENSP00000496829
• ENST00000649267
• ENSP00000497315
• ENST00000649487
• ENSP00000498091
• ENST00000649796
• ENSP00000497260
• ENST00000649855
• ENSP00000497754

Symbol

• Gi

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
interacting protein	0.93
pathway	0.9
transcription factor perturbation	0.88
kinase perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Heterotrimeric G-protein / Guanine Nucleotide-binding Protein G(i) Subunit Alpha-1

DTO Classes

Protein / Enzyme Modulator / G-protein / Heterotrimeric G-protein / Guanine Nucleotide-binding Protein G(i) Subunit Alpha-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.5   (req: < 5)

Gene RIFs: 80   (req: <= 3)

Antibodies: 282   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.5   (req: >= 5)

Gene RIFs: 80   (req: > 3)

Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0