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Tbio
GNA14
Guanine nucleotide-binding protein subunit alpha-14

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341700
  • ENSP00000365807
  • ENSG00000156049
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
gene perturbation
0.97
interacting protein
0.82
PubMedID
0.81
histone modification site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.93   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.93   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (247)
DUSP22
Tbio
Family:  Enzyme
Novelty:  0.01579003
p_int:  0.999631952
p_ni:  0.000368045
p_wrong:  3e-9
Score:  0.27
Data Source:  BioPlex,STRINGDB
GNB4
Tbio
Novelty:  0.08250797
Score:  0.965
Data Source:  STRINGDB
GNB5
Tbio
Novelty:  0.0067714
Score:  0.963
Data Source:  STRINGDB
GNG3
Tbio
Novelty:  0.16941216
Score:  0.962
Data Source:  STRINGDB
GNB2
Tbio
Novelty:  0.08682553
Score:  0.959
Data Source:  STRINGDB
GNG10
Tdark
Novelty:  0.37659459
Score:  0.958
Data Source:  STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.957
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.953
Data Source:  Reactome,STRINGDB
GNG4
Tbio
Novelty:  0.14371438
Score:  0.953
Data Source:  STRINGDB
GNG12
Tbio
Novelty:  0.12611933
Score:  0.952
Data Source:  STRINGDB
Nearest Tclin Targets (28)
Explore Nearest Tclin Targets
1 – 5 of 28
PTGFR
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
CHRM2
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
OXTR
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
PTGER1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
Pathways (43)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
Acetylcholine regulates insulin secretion
Reactome
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Reactome
Free fatty acids regulate insulin secretion
Reactome
G alpha (q) signalling events
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
Acetylcholine regulates insulin secretion
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Free fatty acids regulate insulin secretion
G alpha (q) signalling events
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
1
1
65.4
reticulocyte measurement
1
1
1
64.9
HbA1c measurement
1
1
1
60.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
65.4
reticulocyte measurement
1
64.9
HbA1c measurement
1
60.5
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha 14
VGNC:8888
472961
Macaque
G protein subunit alpha 14
705448
Mouse
MGI:95769
14675
Rat
RGD:1308122
309242
Dog
G protein subunit alpha 14
VGNC:41299
484156
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha 14
Macaque
G protein subunit alpha 14
Mouse
Rat
Dog
G protein subunit alpha 14
Publication Statistics
PubMed Score 17.93
PubMed score by year
PubTator Score 14.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title