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Tbio
GNA12
Guanine nucleotide-binding protein subunit alpha-12

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (P ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275364
  • ENSP00000275364
  • ENSG00000146535
  • ENST00000407904
  • ENSP00000385935

Symbol
  • RMP
  • gep
  • NNX3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
kinase perturbation
0.97
transcription factor perturbation
0.88
trait
0.86
transcription factor binding site profile
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.26   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.26   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (164)
GNA13
Tbio
Novelty:  0.04149138
p_int:  0.975035667
p_ni:  0.024964333
Score:  0.937
Data Source:  BioPlex,STRINGDB
P63092
Tbio
Novelty:  0.00284739
p_int:  0.974796247
p_ni:  0.025203753
Score:  0.74
Data Source:  BioPlex,STRINGDB
GNG2
Tbio
Novelty:  0.04807242
p_int:  0.940376401
p_ni:  0.059623599
Score:  0.943
Data Source:  BioPlex,Reactome,STRINGDB
GNGT1
Tbio
Novelty:  0.05291961
p_int:  0.907228962
p_ni:  0.092771038
Score:  0.953
Data Source:  BioPlex,STRINGDB
RIC8A
Tbio
Novelty:  0.01846696
p_int:  0.781300617
p_ni:  0.218699383
Score:  0.349
Data Source:  BioPlex,STRINGDB
ARHGEF12
Tchem
Novelty:  0.01365866
Score:  0.989
Data Source:  Reactome,STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.975
Data Source:  Reactome,STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.967
Data Source:  STRINGDB
GNG12
Tbio
Novelty:  0.12611933
Score:  0.959
Data Source:  STRINGDB
GNB4
Tbio
Novelty:  0.08250797
Score:  0.958
Data Source:  STRINGDB
Nearest Tclin Targets (16)
Explore Nearest Tclin Targets
Pathways (37)
G alpha (12/13) signalling events (R-HSA-416482)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (12/13) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
G alpha (12/13) signalling events
GPCR downstream signalling
Hemostasis
Platelet activation, signaling and aggregation
Signal Transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
7
7
10
5.9
98.7
BMI-adjusted hip circumference
3
32
38
98.1
BMI-adjusted waist circumference
4
16
19
93.7
platelet crit
2
2
2
84.7
body fat distribution
2
1
5
83.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
10
5.9
98.7
BMI-adjusted hip circumference
38
98.1
BMI-adjusted waist circumference
19
93.7
platelet crit
2
84.7
body fat distribution
5
83.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha 12
VGNC:8679
463234
Macaque
G protein subunit alpha 12
100429106
Mouse
MGI:95767
14673
Rat
RGD:71018
81663
Dog
G protein subunit alpha 12
VGNC:41297
102154318
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha 12
Macaque
G protein subunit alpha 12
Mouse
Rat
Dog
G protein subunit alpha 12
Publication Statistics
PubMed Score 15.26
PubMed score by year
PubTator Score 72.24
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title