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Tchem
GNA11
Guanine nucleotide-binding protein subunit alpha-11

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000078429
  • ENSP00000078429
  • ENSG00000088256

Symbol
  • GA11
  • FBH
  • FBH2
  • FHH2
  • HHC2
  • GNA-11
  • HYPOC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
molecular function
0.99
interacting protein
0.92
kinase perturbation
0.91
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 672.12   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 672.12   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (348)
GNG3
Tbio
Novelty:  0.16941216
p_int:  0.999800076
p_ni:  0.000199924
Score:  0.958
Data Source:  BioPlex,STRINGDB
GNG2
Tbio
Novelty:  0.04807242
p_int:  0.999413076
p_ni:  0.000586924
Score:  0.984
Data Source:  BioPlex,Reactome,STRINGDB
GNGT1
Tbio
Novelty:  0.05291961
p_int:  0.997271418
p_ni:  0.002728582
Score:  0.963
Data Source:  BioPlex,STRINGDB
RIC8A
Tbio
Novelty:  0.01846696
p_int:  0.978997453
p_ni:  0.021002547
Score:  0.424
Data Source:  BioPlex,STRINGDB
PI4K2A
Tbio
Family:  Kinase
Novelty:  0.03506675
p_int:  0.892003745
p_ni:  0.107996255
Data Source:  BioPlex
DUSP22
Tbio
Family:  Enzyme
Novelty:  0.01579003
p_int:  0.868856693
p_ni:  0.131143307
Score:  0.18
Data Source:  BioPlex,STRINGDB
GNG4
Tbio
Novelty:  0.14371438
p_int:  0.78796098
p_ni:  0.21203902
Score:  0.954
Data Source:  BioPlex,STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.995
Data Source:  Reactome,STRINGDB
GNB4
Tbio
Novelty:  0.08250797
Score:  0.992
Data Source:  STRINGDB
GNB2
Tbio
Novelty:  0.08682553
Score:  0.992
Data Source:  STRINGDB
Nearest Tclin Targets (36)
Explore Nearest Tclin Targets
1 – 5 of 33
GNRHR
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
HTR2B
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
HTR2C
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
HTR2A
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
Pathways (64)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

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Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
Acetylcholine regulates insulin secretion
Reactome
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Reactome
Free fatty acids regulate insulin secretion
Reactome
G alpha (q) signalling events
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
Acetylcholine regulates insulin secretion
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Free fatty acids regulate insulin secretion
G alpha (q) signalling events
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
4
4
5
97.9
leukocyte count
2
4
4
97.8
myeloid white cell count
2
2
2
95.4
eosinophil count
3
2
4
92.2
eosinophil percentage of leukocytes
2
2
3
90.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
5
97.9
leukocyte count
4
97.8
myeloid white cell count
2
95.4
eosinophil count
4
92.2
eosinophil percentage of leukocytes
3
90.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
G protein subunit alpha 11
721649
Mouse
MGI:95766
14672
Rat
RGD:619749
81662
Cow
G protein subunit alpha 11
VGNC:29444
281788
Pig
G protein subunit alpha 11
733588
Species
Name
OMA
EggNOG
Inparanoid
Macaque
G protein subunit alpha 11
Mouse
Rat
Cow
G protein subunit alpha 11
Pig
G protein subunit alpha 11
Publication Statistics
PubMed Score 672.12
PubMed score by year
PubTator Score 110.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title