GNA11
Guanine nucleotide-binding protein subunit alpha-11
Protein Summary
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]
- ENST00000078429
- ENSP00000078429
- ENSG00000088256
- GA11
- FBH
- FBH2
- FHH2
- HHC2
- GNA-11
- HYPOC2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.99 | ||
molecular function | 0.99 | ||
interacting protein | 0.92 | ||
kinase perturbation | 0.91 | ||
transcription factor perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 672.12 (req: < 5)
Gene RIFs: 65 (req: <= 3)
Antibodies: 244 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 672.12 (req: >= 5)
Gene RIFs: 65 (req: > 3)
Antibodies: 244 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (3)
Protein-Protein Interactions (348)
GNG3
Novelty: 0.16941216
p_int: 0.999800076
p_ni: 0.000199924
Score: 0.958
Data Source: BioPlex,STRINGDB
GNG2
Novelty: 0.04807242
p_int: 0.999413076
p_ni: 0.000586924
Score: 0.984
Data Source: BioPlex,Reactome,STRINGDB
GNGT1
Novelty: 0.05291961
p_int: 0.997271418
p_ni: 0.002728582
Score: 0.963
Data Source: BioPlex,STRINGDB
RIC8A
Novelty: 0.01846696
p_int: 0.978997453
p_ni: 0.021002547
Score: 0.424
Data Source: BioPlex,STRINGDB
PI4K2A
Family: Kinase
Novelty: 0.03506675
p_int: 0.892003745
p_ni: 0.107996255
Data Source: BioPlex
DUSP22
Family: Enzyme
Novelty: 0.01579003
p_int: 0.868856693
p_ni: 0.131143307
Score: 0.18
Data Source: BioPlex,STRINGDB
GNG4
Novelty: 0.14371438
p_int: 0.78796098
p_ni: 0.21203902
Score: 0.954
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (36)
Upstream (33)
Downstream (3)
1 – 5 of 33
Pathways (64)
Reactome (16)
KEGG (18)
PathwayCommons (24)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ADP signalling through P2Y purinoceptor 1 | ||||
Reactome | Acetylcholine regulates insulin secretion | ||||
Reactome | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | ||||
Reactome | Free fatty acids regulate insulin secretion | ||||
Reactome | G alpha (q) signalling events | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ADP signalling through P2Y purinoceptor 1 | ||||
Acetylcholine regulates insulin secretion | ||||
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | ||||
Free fatty acids regulate insulin secretion | ||||
G alpha (q) signalling events | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (6)
Components (6)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (25)
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 4 | 4 | 5 | 97.9 | |||||
leukocyte count | 2 | 4 | 4 | 97.8 | |||||
myeloid white cell count | 2 | 2 | 2 | 95.4 | |||||
eosinophil count | 3 | 2 | 4 | 92.2 | |||||
eosinophil percentage of leukocytes | 2 | 2 | 3 | 90.9 | |||||
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 5 | 97.9 | |||||
leukocyte count | 4 | 97.8 | |||||
myeloid white cell count | 2 | 95.4 | |||||
eosinophil count | 4 | 92.2 | |||||
eosinophil percentage of leukocytes | 3 | 90.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | G protein subunit alpha 11 | 721649 | ||||||
Mouse | MGI:95766 | 14672 | ||||||
Rat | RGD:619749 | 81662 | ||||||
Cow | G protein subunit alpha 11 | VGNC:29444 | 281788 | |||||
Pig | G protein subunit alpha 11 | 733588 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | G protein subunit alpha 11 | |||||
Mouse | ||||||
Rat | ||||||
Cow | G protein subunit alpha 11 | |||||
Pig | G protein subunit alpha 11 | |||||
Publication Statistics
PubMed Score 672.12
PubMed score by year
PubTator Score 110.07
PubTator score by year
Related Publications
Text Mined References (105)
GeneRif Annotations (65)
Items per page:
0 of 0
PMID | Year | Title |
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