GNA11
Guanine nucleotide-binding protein subunit alpha-11
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.99 | ||
molecular function | 0.99 | ||
interacting protein | 0.92 | ||
kinase perturbation | 0.91 | ||
transcription factor perturbation | 0.84 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | ADP signalling through P2Y purinoceptor 1 | ||||
Reactome | Acetylcholine regulates insulin secretion | ||||
Reactome | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | ||||
Reactome | Free fatty acids regulate insulin secretion | ||||
Reactome | G alpha (q) signalling events | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
ADP signalling through P2Y purinoceptor 1 | ||||
Acetylcholine regulates insulin secretion | ||||
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | ||||
Free fatty acids regulate insulin secretion | ||||
G alpha (q) signalling events | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
neutrophil count | 4 | 4 | 5 | 97.9 | |||||
leukocyte count | 2 | 4 | 4 | 97.8 | |||||
myeloid white cell count | 2 | 2 | 2 | 95.4 | |||||
eosinophil count | 3 | 2 | 4 | 92.2 | |||||
eosinophil percentage of leukocytes | 2 | 2 | 3 | 90.9 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
neutrophil count | 5 | 97.9 | |||||
leukocyte count | 4 | 97.8 | |||||
myeloid white cell count | 2 | 95.4 | |||||
eosinophil count | 4 | 92.2 | |||||
eosinophil percentage of leukocytes | 3 | 90.9 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | G protein subunit alpha 11 | 721649 | ||||||
Mouse | MGI:95766 | 14672 | ||||||
Rat | RGD:619749 | 81662 | ||||||
Cow | G protein subunit alpha 11 | VGNC:29444 | 281788 | |||||
Pig | G protein subunit alpha 11 | 733588 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | G protein subunit alpha 11 | |||||
Mouse | ||||||
Rat | ||||||
Cow | G protein subunit alpha 11 | |||||
Pig | G protein subunit alpha 11 | |||||
PMID | Year | Title |
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