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Tbio
GMPPB
Mannose-1-phosphate guanyltransferase beta

Protein Summary
Description
Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. This gene is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308375
  • ENSP00000309092
  • ENSG00000173540
  • ENST00000308388
  • ENSP00000311130
  • ENST00000480687
  • ENSP00000418565

Symbol
  • LGMDR19
  • MDDGA14
  • MDDGB14
  • MDDGC14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
histone modification site profile
0.86
phenotype
0.73
transcription factor perturbation
0.68
transcription factor
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.95   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.95   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (109)
GMPPA
Tbio
Family:  Enzyme
Novelty:  0.14050797
p_int:  0.998291508
p_ni:  0.001708492
Score:  0.996
Data Source:  BioPlex,STRINGDB
PRUNE1
Tchem
Novelty:  0.02136836
p_int:  0.998164019
p_ni:  0.001778771
p_wrong:  0.00005721
Score:  0.529
Data Source:  BioPlex,STRINGDB
PI4K2B
Tbio
Family:  Enzyme
Novelty:  0.19272599
p_int:  0.993972612
p_ni:  0.006027388
Score:  0.224
Data Source:  BioPlex,STRINGDB
PRMT3
Tchem
Family:  Epigenetic
Novelty:  0.03433797
p_int:  0.993323583
p_ni:  0.005882722
p_wrong:  0.000793695
Score:  0.311
Data Source:  BioPlex,STRINGDB
GOLPH3
Tbio
Novelty:  0.00020234
p_int:  0.97858246
p_ni:  0.02141754
Score:  0.649
Data Source:  BioPlex,STRINGDB
CCNB2
Tbio
Novelty:  0.00672914
p_int:  0.776519564
p_ni:  0.00999454
p_wrong:  0.213485897
Score:  0.253
Data Source:  BioPlex,STRINGDB
DPM1
Tbio
Family:  Enzyme
Novelty:  0.01317862
Score:  0.979
Data Source:  STRINGDB
PMM2
Tchem
Family:  Enzyme
Novelty:  0.01177513
Score:  0.969
Data Source:  STRINGDB
PMM1
Tbio
Family:  Enzyme
Novelty:  0.03310193
Score:  0.967
Data Source:  STRINGDB
GMDS
Tbio
Family:  Enzyme
Novelty:  0.00622275
Score:  0.96
Data Source:  STRINGDB
Pathways (15)
Asparagine N-linked glycosylation (R-HSA-446203)

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1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of GDP-mannose
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Synthesis of GDP-mannose
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
5
5
4
8.2
98.6
intelligence
4
9
4
7.4
96.1
reticulocyte count
1
2
2
93.4
mathematical ability
3
3
3
92.6
household income
2
4
5
92.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
8.2
98.6
intelligence
4
7.4
96.1
reticulocyte count
2
93.4
mathematical ability
3
92.6
household income
5
92.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GDP-mannose pyrophosphorylase B
VGNC:7063
460378
Macaque
GDP-mannose pyrophosphorylase B
705454
Mouse
MGI:2660880
331026
Rat
RGD:1560458
363145
Dog
GDP-mannose pyrophosphorylase B
VGNC:41293
100856660
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GDP-mannose pyrophosphorylase B
Macaque
GDP-mannose pyrophosphorylase B
Mouse
Rat
Dog
GDP-mannose pyrophosphorylase B
Publication Statistics
PubMed Score 26.95
PubMed score by year
PubTator Score 17.43
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title