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Tdark
GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

Protein Summary
Description
May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220940
  • ENSP00000220940
  • ENSG00000104499

Symbol
  • LY6DL
  • LY6DL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.66
tissue
0.66
disease perturbation
0.62
cell line
0.5
disease
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.01   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.01   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
EIF2A
Tbio
Novelty:  0.08652858
p_int:  0.99525506
p_ni:  0.003161702
p_wrong:  0.001583238
Data Source:  BioPlex
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.982558139
p_ni:  0.017441861
Data Source:  BioPlex
LSS
Tchem
Family:  Enzyme
Novelty:  0.00735187
p_int:  0.980959831
p_ni:  0.009792443
p_wrong:  0.009247726
Score:  0.173
Data Source:  BioPlex,STRINGDB
CNTNAP3
Tbio
Novelty:  0.22791524
p_int:  0.97564611
p_ni:  0.024353883
p_wrong:  7e-9
Data Source:  BioPlex
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.972639509
p_ni:  0.027209607
p_wrong:  0.000150884
Data Source:  BioPlex
LAMA3
Tbio
Novelty:  0.00733792
p_int:  0.971882939
p_ni:  0.027891587
p_wrong:  0.000225475
Data Source:  BioPlex
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.958346173
p_ni:  0.041653827
Data Source:  BioPlex
LAMB2
Tbio
Novelty:  0.07966931
p_int:  0.941151601
p_ni:  0.058848399
Data Source:  BioPlex
TMEM67
Tbio
Novelty:  0.02573267
p_int:  0.940505443
p_ni:  0.059494318
p_wrong:  2.39e-7
Data Source:  BioPlex
TUBA1A
Tchem
Novelty:  0.01030145
p_int:  0.930200487
p_ni:  0.069799513
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Attenuation phase (R-HSA-3371568)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attenuation phase
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
HSF1 activation
Name
Explore in Pharos
Explore in Source
Attenuation phase
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
HSF1 activation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
3
3
94.5
1
3
3
66.2
diastolic blood pressure
2
4
4
65.4
androstenedione measurement
1
3
3
55.2
systolic blood pressure
1
1
1
53.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
94.5
3
66.2
diastolic blood pressure
4
65.4
androstenedione measurement
3
55.2
systolic blood pressure
1
53.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycosylphosphatidylinositol anchored molecule like
VGNC:12184
472878
Macaque
glycosylphosphatidylinositol anchored molecule like
705046
Mouse
MGI:1341831
15202
Rat
RGD:1307850
300019
Horse
glycosylphosphatidylinositol anchored molecule like [Source:HGNC Symbol;Acc:HGNC:4375]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycosylphosphatidylinositol anchored molecule like
Macaque
glycosylphosphatidylinositol anchored molecule like
Mouse
Rat
Horse
glycosylphosphatidylinositol anchored molecule like [Source:HGNC Symbol;Acc:HGNC:4375]
Publication Statistics
PubMed Score 21.01
PubMed score by year
PubTator Score 17.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title