Tbio GMIP GEM-interacting protein

Protein Summary

Description

Stimulates, in vitro and in vivo, the GTPase activity of RhoA. This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• Q9P107
• A0AVN9
• B7ZLZ0
• GMIP

Gene Name

• GMIP

Ensembl ID

• ENST00000203556
• ENSP00000203556
• ENSG00000089639
• ENST00000587238
• ENSP00000467054

Symbol

• ARHGAP46

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.86
metabolite	0.82
histone modification site profile	0.75
co-expressed gene	0.69
small molecule perturbation	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.83   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 70   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.83   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0