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Tbio
GMFB
Glia maturation factor beta

Protein Summary
Description
This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358056
  • ENSP00000350757
  • ENSG00000197045
  • ENST00000616146
  • ENSP00000479543

Symbol
  • GMF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.85
histone modification site profile
0.85
transcription factor perturbation
0.84
disease perturbation
0.83
transcription factor binding site profile
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.29   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.29   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
GMFG
Tbio
Novelty:  0.0893982
p_int:  0.999999923
p_ni:  5e-8
p_wrong:  2.7e-8
Data Source:  BioPlex
HSPA1A
Tchem
Novelty:  0.00069195
p_int:  0.99999973
p_ni:  2.7e-7
Data Source:  BioPlex
CARM1
Tchem
Family:  Epigenetic
Novelty:  0.00623937
p_int:  0.999863819
p_ni:  0.000136181
Data Source:  BioPlex
RAB3GAP1
Tbio
Family:  Enzyme
Novelty:  0.0286836
p_int:  0.999833743
p_ni:  0.000166256
p_wrong:  1e-9
Data Source:  BioPlex
ALAD
Tbio
Family:  Enzyme
Novelty:  0.00092757
p_int:  0.999754943
p_ni:  0.000090694
p_wrong:  0.000154363
Data Source:  BioPlex
ACADL
Tbio
Family:  Enzyme
Novelty:  0.0298212
p_int:  0.999544513
p_ni:  0.000454503
p_wrong:  9.84e-7
Data Source:  BioPlex
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.956326795
p_ni:  0.043673205
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.874058997
p_ni:  0.125941003
Data Source:  BioPlex
SPAG9
Tbio
Family:  Enzyme
Novelty:  0.00527315
p_int:  0.848965268
p_ni:  0.151034732
Data Source:  BioPlex
ACTR2
Tchem
Novelty:  0.00731489
Score:  0.882
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
46.5
red blood cell distribution width
1
1
1
37.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
46.5
red blood cell distribution width
1
37.7
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glia maturation factor beta
VGNC:7519
743468
Macaque
glia maturation factor beta
696440
Mouse
MGI:1927133
63985
Rat
RGD:70910
81661
Dog
glia maturation factor beta
VGNC:41288
100856272
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glia maturation factor beta
Macaque
glia maturation factor beta
Mouse
Rat
Dog
glia maturation factor beta
Publication Statistics
PubMed Score 88.29
PubMed score by year
PubTator Score 67.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title