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Tdark
GMEB2
Glucocorticoid modulatory element-binding protein 2

Protein Summary
Description
Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266068
  • ENSP00000266068
  • ENSG00000101216
  • ENST00000370077
  • ENSP00000359094

Symbol
  • KIAA1269
  • PIF79
  • GMEB-2
  • P79PIF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor binding site profile
0.74
tissue sample
0.7
cell type or tissue
0.66
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.41   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.41   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
GMEB1
Tbio
Family:  TF
Novelty:  0.10522678
p_int:  0.99999999
p_ni:  2e-9
p_wrong:  8e-9
Score:  0.927
Data Source:  BioPlex,STRINGDB
CD44
Tbio
Novelty:  0.00011321
p_int:  0.99999877
p_ni:  1.25e-7
p_wrong:  0.000001105
Score:  0.439
Data Source:  BioPlex,STRINGDB
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.999984244
p_ni:  0.000015237
p_wrong:  5.19e-7
Score:  0.306
Data Source:  BioPlex,STRINGDB
SDC1
Tbio
Novelty:  0.00044792
p_int:  0.999970602
p_ni:  0.000028782
p_wrong:  6.16e-7
Score:  0.663
Data Source:  BioPlex,STRINGDB
IL7R
Tbio
Novelty:  0.00107223
p_int:  0.999786861
p_ni:  0.000028288
p_wrong:  0.000184852
Data Source:  BioPlex
ZGPAT
Tbio
Family:  Epigenetic
Novelty:  0.16971298
Score:  0.685
Data Source:  STRINGDB
NELFB
Tbio
Novelty:  0.05821821
Score:  0.667
Data Source:  STRINGDB
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.645
Data Source:  STRINGDB
TFRC
Tbio
Novelty:  0.00025984
Score:  0.641
Data Source:  STRINGDB
ZMIZ2
Tbio
Family:  TF
Novelty:  0.28069625
Score:  0.601
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (46)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
4
0
1.4
96.6
8
3
0
1.4
94.9
glioblastoma multiforme
3
2
0
1.4
92.5
2
2
0
1.2
87.5
glomerular filtration rate
4
5
4
6
87
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
96.6
0
1.4
94.9
glioblastoma multiforme
0
1.4
92.5
0
1.2
87.5
glomerular filtration rate
4
6
87
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucocorticoid modulatory element binding protein 2
VGNC:14138
458411
Mouse
MGI:2652836
229004
Rat
RGD:620481
83635
Dog
glucocorticoid modulatory element binding protein 2
VGNC:41287
485975
Horse
glucocorticoid modulatory element binding protein 2
VGNC:18403
100060635
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucocorticoid modulatory element binding protein 2
Mouse
Rat
Dog
glucocorticoid modulatory element binding protein 2
Horse
glucocorticoid modulatory element binding protein 2
Publication Statistics
PubMed Score 4.41
PubMed score by year
PubTator Score 5.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title