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Tbio
GMEB1
Glucocorticoid modulatory element-binding protein 1

Protein Summary
Description
Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294409
  • ENSP00000294409
  • ENSG00000162419
  • ENST00000361872
  • ENSP00000355186
  • ENST00000373816
  • ENSP00000362922

Symbol
  • PIF96
  • P96PIF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
small molecule perturbation
0.68
transcription factor
0.57
cell type or tissue
0.54
transcription factor perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.81   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.81   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
GMEB2
Tdark
Family:  TF
Novelty:  0.1945427
p_int:  0.99999999
p_ni:  2e-9
p_wrong:  8e-9
Score:  0.927
Data Source:  BioPlex,STRINGDB
CD44
Tbio
Novelty:  0.00011321
p_int:  0.999998072
p_ni:  0.000001921
p_wrong:  7e-9
Score:  0.439
Data Source:  BioPlex,STRINGDB
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.999994638
p_ni:  0.000005362
Score:  0.306
Data Source:  BioPlex,STRINGDB
IL7R
Tbio
Novelty:  0.00107223
p_int:  0.999987856
p_ni:  0.000012135
p_wrong:  8e-9
Data Source:  BioPlex
RABEPK
Tdark
Novelty:  0.97019495
p_int:  0.999338254
p_ni:  0.000548643
p_wrong:  0.000113104
Data Source:  BioPlex
MATN4
Tdark
Novelty:  0.31964843
p_int:  0.998294413
p_ni:  0.001705586
Score:  0.188
Data Source:  BioPlex,STRINGDB
DHRS2
Tbio
Family:  Enzyme
Novelty:  0.002032
p_int:  0.994926041
p_ni:  0.00183638
p_wrong:  0.003237579
Score:  0.848
Data Source:  BioPlex,STRINGDB
WDR54
Tdark
Novelty:  1.19807122
p_int:  0.981781944
p_ni:  0.018218056
Score:  0.179
Data Source:  BioPlex,STRINGDB
SDC1
Tbio
Novelty:  0.00044792
p_int:  0.930106296
p_ni:  0.004342799
p_wrong:  0.065550905
Score:  0.663
Data Source:  BioPlex,STRINGDB
MORC1
Tbio
Novelty:  0.0182807
p_int:  0.912790364
p_ni:  0.002086364
p_wrong:  0.085123272
Score:  0.19
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
2
2
50.6
2
2
2
49.1
IGF-1 measurement
1
1
1
42.3
self reported educational attainment
1
1
1
24.5
1
1
0
1.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
50.6
2
49.1
IGF-1 measurement
1
42.3
self reported educational attainment
1
24.5
0
1.1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucocorticoid modulatory element binding protein 1
VGNC:1253
469252
Mouse
MGI:2135604
56809
Rat
RGD:1563208
500558
Dog
glucocorticoid modulatory element binding protein 1
VGNC:41286
487330
Horse
glucocorticoid modulatory element binding protein 1
VGNC:18402
100056460
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucocorticoid modulatory element binding protein 1
Mouse
Rat
Dog
glucocorticoid modulatory element binding protein 1
Horse
glucocorticoid modulatory element binding protein 1
Publication Statistics
PubMed Score 12.81
PubMed score by year
PubTator Score 7.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title