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Tbio
GMDS
GDP-mannose 4,6 dehydratase

Protein Summary
Description
Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380815
  • ENSP00000370194
  • ENSG00000112699
  • ENST00000530927
  • ENSP00000436726

Symbol
  • GMD
  • SDR3E1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
disease perturbation
0.87
kinase perturbation
0.81
transcription factor binding site profile
0.8
trait
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.03   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.03   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
TNKS2
Tchem
Family:  Enzyme
Novelty:  0.00938509
p_int:  0.99999891
p_ni:  0.00000109
Score:  0.827
Data Source:  BioPlex,STRINGDB
TNKS
Tchem
Family:  Enzyme
Novelty:  0.00404545
p_int:  0.999991377
p_ni:  0.000008623
Score:  0.922
Data Source:  BioPlex,STRINGDB
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  0.99253866
p_ni:  0.00746134
Score:  0.554
Data Source:  BioPlex,STRINGDB
PPP1R12B
Tbio
Family:  Enzyme
Novelty:  0.0424259
p_int:  0.958590528
p_ni:  0.041409459
p_wrong:  1.3e-8
Data Source:  BioPlex
NPHP3
Tbio
Novelty:  0.02857926
p_int:  0.945208165
p_ni:  0.054791835
Score:  0.257
Data Source:  BioPlex,STRINGDB
TSTA3
Tbio
Family:  Enzyme
Novelty:  0.03669619
Score:  0.999
Data Source:  STRINGDB
GMPPB
Tbio
Family:  Enzyme
Novelty:  0.05106206
Score:  0.96
Data Source:  STRINGDB
GMPPA
Tbio
Family:  Enzyme
Novelty:  0.14050797
Score:  0.943
Data Source:  STRINGDB
DPM1
Tbio
Family:  Enzyme
Novelty:  0.01317862
Score:  0.871
Data Source:  STRINGDB
ALG1
Tbio
Family:  Enzyme
Novelty:  0.012911
Score:  0.857
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
GDP-fucose biosynthesis
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
GDP-fucose biosynthesis
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
8
15
94.9
hematocrit
3
2
4
92.4
hemoglobin measurement
3
2
4
91.7
heel bone mineral density
2
4
4
86.3
red blood cell density measurement
1
1
1
82.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
15
94.9
hematocrit
4
92.4
hemoglobin measurement
4
91.7
heel bone mineral density
4
86.3
red blood cell density measurement
1
82.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GDP-mannose 4,6-dehydratase
VGNC:52010
462390
Macaque
GDP-mannose 4,6-dehydratase
707051
Mouse
MGI:1891112
218138
Rat
RGD:1311008
291095
Dog
GDP-mannose 4,6-dehydratase [Source:HGNC Symbol;Acc:HGNC:4369]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GDP-mannose 4,6-dehydratase
Macaque
GDP-mannose 4,6-dehydratase
Mouse
Rat
Dog
GDP-mannose 4,6-dehydratase [Source:HGNC Symbol;Acc:HGNC:4369]
Publication Statistics
PubMed Score 157.03
PubMed score by year
PubTator Score 14.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title