You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GMCL1
Germ cell-less protein-like 1

Protein Summary
Description
Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). This gene encodes a nuclear envelope protein that appears to be involved in spermatogenesis, either directly or by influencing genes that play a more direct role in the process. This multi-exon locus is the homolog of the mouse and drosophila germ cell-less gene but the human genome also contains a single-exon locus on chromosome 5 that contains an open reading frame capable of encoding a highly-related protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282570
  • ENSP00000282570
  • ENSG00000087338

Symbol
  • GCL
  • GCL
  • GCL1
  • BTBD13
  • SPATA29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
transcription factor perturbation
0.88
histone modification site profile
0.74
disease perturbation
0.68
tissue sample
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.33   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.33   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
MBIP
Tbio
Novelty:  0.05807454
p_int:  0.999996999
p_ni:  0.000003001
Data Source:  BioPlex
P2RX1
Tchem
Family:  IC
Novelty:  0.00286826
p_int:  0.999992376
p_ni:  0.000007621
p_wrong:  3e-9
Data Source:  BioPlex
SYT12
Tbio
Novelty:  0.03410873
p_int:  0.99999219
p_ni:  0.00000781
Data Source:  BioPlex
CLCC1
Tbio
Family:  IC
Novelty:  0.06584842
p_int:  0.999962261
p_ni:  0.000037738
p_wrong:  1e-9
Data Source:  BioPlex
TMEM98
Tbio
Novelty:  0.10281593
p_int:  0.999879649
p_ni:  0.000120306
p_wrong:  4.5e-8
Data Source:  BioPlex
PLBD1
Tdark
Family:  Enzyme
Novelty:  0.27639575
p_int:  0.999869669
p_ni:  0.000130175
p_wrong:  1.56e-7
Data Source:  BioPlex
MBLAC2
Tdark
Family:  Enzyme
Novelty:  0.47407992
p_int:  0.999845878
p_ni:  0.00015394
p_wrong:  1.82e-7
Data Source:  BioPlex
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.999808386
p_ni:  0.000191614
p_wrong:  1e-9
Score:  0.686
Data Source:  BioPlex,STRINGDB
NCOA4
Tbio
Novelty:  0.00487453
p_int:  0.999803746
p_ni:  0.00019473
p_wrong:  0.000001524
Score:  0.183
Data Source:  BioPlex,STRINGDB
KLK7
Tchem
Family:  Enzyme
Novelty:  0.00757766
p_int:  0.999579667
p_ni:  0.000400422
p_wrong:  0.000019911
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
3
92.7
4
5
0
1.1
88.8
platelet count
2
2
2
82.6
red blood cell distribution width
3
3
3
64.9
reticulocyte count
3
2
3
54.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
92.7
0
1.1
88.8
platelet count
2
82.6
red blood cell distribution width
3
64.9
reticulocyte count
3
54.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
germ cell-less, spermatogenesis associated 1
459298
Mouse
MGI:1345156
23885
Dog
germ cell-less, spermatogenesis associated 1
481414
Horse
germ cell-less, spermatogenesis associated 1
100060991
Cow
germ cell-less, spermatogenesis associated 1
513934
Species
Name
OMA
EggNOG
Inparanoid
Chimp
germ cell-less, spermatogenesis associated 1
Mouse
Dog
germ cell-less, spermatogenesis associated 1
Horse
germ cell-less, spermatogenesis associated 1
Cow
germ cell-less, spermatogenesis associated 1
Publication Statistics
PubMed Score 7.33
PubMed score by year
PubTator Score 5.17
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title