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Tbio
GM2A
Ganglioside GM2 activator

Protein Summary
Description
The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants. [provi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357164
  • ENSP00000349687
  • ENSG00000196743

Symbol
  • SAP-3
  • GM2-AP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.98
kinase perturbation
0.98
interacting protein
0.94
cellular component
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.36   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 444   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.36   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 444   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (149)
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.987383004
p_ni:  0.01261692
p_wrong:  7.6e-8
Data Source:  BioPlex
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.98614887
p_ni:  0.013851094
p_wrong:  3.6e-8
Data Source:  BioPlex
KIR3DS1
Tdark
p_int:  0.947198265
p_ni:  0.052798478
p_wrong:  0.000003257
Data Source:  BioPlex
SSBP4
Tdark
Novelty:  0.27365687
p_int:  0.947198265
p_ni:  0.052798478
p_wrong:  0.000003257
Data Source:  BioPlex
SF3A1
Tbio
Novelty:  0.03405702
p_int:  0.941222196
p_ni:  0.058777804
Data Source:  BioPlex
SINHCAF
Tdark
Novelty:  0.18692832
p_int:  0.939179198
p_ni:  0.060816207
p_wrong:  0.000004595
Score:  0.278
Data Source:  BioPlex,STRINGDB
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.927279825
p_ni:  0.072719829
p_wrong:  3.46e-7
Data Source:  BioPlex
CCDC51
Tdark
Novelty:  1.19203634
p_int:  0.92533263
p_ni:  0.074667364
p_wrong:  6e-9
Data Source:  BioPlex
POC5
Tbio
Novelty:  0.09211907
p_int:  0.904031796
p_ni:  0.095968204
Score:  0.183
Data Source:  BioPlex,STRINGDB
AIRE
Tbio
Family:  TF; Epigenetic
Novelty:  0.00158659
p_int:  0.898795256
p_ni:  0.101204744
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Glycosphingolipid metabolism (R-HSA-1660662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosphingolipid metabolism
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Glycosphingolipid metabolism
Immune System
Innate Immune System
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
3
84.1
red blood cell distribution width
2
1
2
81.7
myeloid white cell count
1
1
1
71.6
leukocyte count
2
1
2
68.8
monocyte count
2
1
2
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
84.1
red blood cell distribution width
2
81.7
myeloid white cell count
1
71.6
leukocyte count
2
68.8
monocyte count
2
66.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GM2 ganglioside activator
VGNC:11953
471705
Macaque
GM2 ganglioside activator
713375
Mouse
MGI:95762
14667
Rat
RGD:628651
282838
Dog
GM2 ganglioside activator
VGNC:41285
100855818
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GM2 ganglioside activator
Macaque
GM2 ganglioside activator
Mouse
Rat
Dog
GM2 ganglioside activator
Publication Statistics
PubMed Score 178.36
PubMed score by year
PubTator Score 65.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title