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Tbio
GLYR1
Putative oxidoreductase GLYR1

Protein Summary
Description
Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity (PubMed:23260659). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (PubMed:20850016). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321919
  • ENSP00000322716
  • ENSG00000140632
  • ENST00000436648
  • ENSP00000390276
  • ENST00000591451
  • ENSP00000468328

Symbol
  • HIBDL
  • NP60
  • NP60
  • BM045
  • HIBDL
  • N-PAC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
interacting protein
0.84
disease perturbation
0.83
transcription factor perturbation
0.8
small molecule perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.75   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.75   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
KDM1B
Tbio
Family:  Epigenetic
Novelty:  0.02174039
p_int:  0.999998651
p_ni:  0.000001349
Score:  0.566
Data Source:  BioPlex,STRINGDB
MAGEA1
Tbio
Novelty:  0.00506874
p_int:  0.997868906
p_ni:  0.002131094
Data Source:  BioPlex
WDR46
Tbio
Novelty:  0.19307408
p_int:  0.985121707
p_ni:  0.014878293
Data Source:  BioPlex
ZNF2
Tbio
Family:  TF
Novelty:  0.01062543
p_int:  0.97401479
p_ni:  0.02598521
Score:  0.252
Data Source:  BioPlex,STRINGDB
SERPINA12
Tbio
Novelty:  0.00549132
p_int:  0.968486473
p_ni:  0.031513527
Data Source:  BioPlex
RPL8
Tbio
Novelty:  0.01064076
p_int:  0.964211397
p_ni:  0.035788603
Score:  0.561
Data Source:  BioPlex,STRINGDB
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.961462004
p_ni:  0.038183319
p_wrong:  0.000354677
Data Source:  BioPlex
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.956444841
p_ni:  0.043555159
Score:  0.303
Data Source:  BioPlex,STRINGDB
NOP53
Tbio
Novelty:  0.00353077
p_int:  0.952648844
p_ni:  0.047351156
Score:  0.221
Data Source:  BioPlex,STRINGDB
RPL28
Tbio
Novelty:  0.03136035
p_int:  0.949494288
p_ni:  0.050505712
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
72.8
mean platelet volume
1
1
1
58.4
waist-hip ratio
2
2
2
49.2
BMI-adjusted waist circumference
1
3
3
47.5
diastolic blood pressure
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
72.8
mean platelet volume
1
58.4
waist-hip ratio
2
49.2
BMI-adjusted waist circumference
3
47.5
diastolic blood pressure
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glyoxylate reductase 1 homolog
VGNC:9082
748328
Macaque
glyoxylate reductase 1 homolog
706933
Mouse
MGI:1921272
74022
Rat
RGD:1309459
360477
Dog
glyoxylate reductase 1 homolog
VGNC:41284
479860
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glyoxylate reductase 1 homolog
Macaque
glyoxylate reductase 1 homolog
Mouse
Rat
Dog
glyoxylate reductase 1 homolog
Publication Statistics
PubMed Score 28.75
PubMed score by year
PubTator Score 9.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title