Protein Summary
Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:30158707, PubMed:16267323). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed:30158707). The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammo ...more
- ENST00000311223
- ENSP00000307900
- ENSG00000135821
- ENST00000331872
- ENSP00000356537
- ENST00000339526
- ENSP00000344958
- ENST00000417584
- ENSP00000398320
- GLNS
- GS
- GLNS
- PIG43
- PIG59
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 1 | ||
molecular function | 1 | ||
disease perturbation | 0.99 | ||
transcription factor perturbation | 0.97 | ||
PubMedID | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 965.17 (req: < 5)
Gene RIFs: 47 (req: <= 3)
Antibodies: 590 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 965.17 (req: >= 5)
Gene RIFs: 47 (req: > 3)
Antibodies: 590 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 8
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (8)
Protein-Protein Interactions (247)
TCHP
Novelty: 0.00053696
p_int: 0.999999653
p_ni: 2e-9
p_wrong: 3.44e-7
Score: 0.541
Data Source: BioPlex,STRINGDB
NME7
Family: Enzyme
Novelty: 0.08546782
p_int: 0.999907066
p_ni: 0.000092922
p_wrong: 1.1e-8
Score: 0.308
Data Source: BioPlex,STRINGDB
ASPSCR1
Novelty: 0.01172319
p_int: 0.997579272
p_ni: 0.002420727
Score: 0.497
Data Source: BioPlex,STRINGDB
DMXL2
Novelty: 0.06848356
p_int: 0.99102745
p_ni: 0.008972295
p_wrong: 2.54e-7
Score: 0.211
Data Source: BioPlex,STRINGDB
ZFAND2B
Novelty: 0.28286118
p_int: 0.940934685
p_ni: 0.059065315
Score: 0.19
Data Source: BioPlex,STRINGDB
C1orf94
Novelty: 23
p_int: 0.838068305
p_ni: 0.161931695
Score: 0.187
Data Source: BioPlex,STRINGDB
RNASEH2C
Family: Enzyme
Novelty: 0.06148299
p_int: 0.751941926
p_ni: 0.248058074
Data Source: BioPlex
Nearest Tclin Targets (3)
Upstream (2)
Downstream (1)
Pathways (27)
Reactome (7)
KEGG (9)
PathwayCommons (5)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Astrocytic Glutamate-Glutamine Uptake And Metabolism | ||||
Reactome | Glutamate and glutamine metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Neuronal System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Astrocytic Glutamate-Glutamine Uptake And Metabolism | ||||
Glutamate and glutamine metabolism | ||||
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Neuronal System | ||||
Viral Interactions (0)
Gene Ontology Terms (32)
Functions (8)
Components (11)
Processes (13)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
chronotype measurement | 1 | 2 | 0 | 1.3 | 83.5 | ||||
electrocardiography | 1 | 1 | 44 | 12.9 | |||||
red blood cell distribution width | 1 | 1 | 1 | 9.9 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 2 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
chronotype measurement | 0 | 1.3 | 83.5 | ||||
electrocardiography | 44 | 12.9 | |||||
red blood cell distribution width | 1 | 9.9 | |||||
high density lipoprotein cholesterol measurement | 1 | 2 | |||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | glutamate-ammonia ligase | VGNC:11441 | 456450 | |||||
Macaque | glutamate-ammonia ligase | 715952 | ||||||
Mouse | MGI:95739 | 14645 | ||||||
Rat | RGD:2710 | 24957 | ||||||
Dog | glutamate-ammonia ligase | 403443 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | glutamate-ammonia ligase | |||||
Macaque | glutamate-ammonia ligase | |||||
Mouse | ||||||
Rat | ||||||
Dog | glutamate-ammonia ligase | |||||
Publication Statistics
PubMed Score 965.17
PubMed score by year
PubTator Score 1793.10
PubTator score by year
Related Publications
GeneRif Annotations (47)
Items per page:
0 of 0
PMID | Text |
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