Tbio GLUD2 Glutamate dehydrogenase 2, mitochondrial

Protein Summary

Description

Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission. The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• P49448
• B2R8G0
• Q9UDQ4
• GDH 2

Gene Name

• GLUD2

Ensembl ID

• ENST00000328078
• ENSP00000327589
• ENSG00000182890

Symbol

• GLUDP1
• GDH2
• GLUDP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.97
tissue	0.65
pathway	0.59
protein domain	0.58
tissue sample	0.57

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / Glutamate Dehydrogenase 2, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Glutamate Dehydrogenase 2, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.44   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 208   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.44   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0