Tbio GLTP Glycolipid transfer protein

Protein Summary

Description

Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides. The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NZD2
• Q53Z13
• Q96J68
• GLTP

Gene Name

• GLTP

Ensembl ID

• ENST00000318348
• ENSP00000315263
• ENSG00000139433

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.9
kinase perturbation	0.84
transcription factor perturbation	0.74
transcription factor binding site profile	0.66
tissue sample	0.63

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Glycolipid Transfer Protein

DTO Classes

Protein / Transporter / Glycolipid Transfer Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.04   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 93   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.04   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0