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Tbio
GLTP
Glycolipid transfer protein

Protein Summary
Description
Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides. The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318348
  • ENSP00000315263
  • ENSG00000139433
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
kinase perturbation
0.84
transcription factor perturbation
0.74
transcription factor binding site profile
0.66
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.46   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.46   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
STARD7
Tbio
Novelty:  0.04511594
p_int:  0.980286007
p_ni:  0.019713219
p_wrong:  7.74e-7
Score:  0.289
Data Source:  BioPlex,STRINGDB
ASPSCR1
Tbio
Novelty:  0.01172319
p_int:  0.944142083
p_ni:  0.055857916
p_wrong:  1e-9
Score:  0.734
Data Source:  BioPlex,STRINGDB
SHKBP1
Tbio
Novelty:  0.00235279
p_int:  0.934426333
p_ni:  0.065573667
Score:  0.679
Data Source:  BioPlex,STRINGDB
AMD1
Tchem
Family:  Enzyme
Novelty:  0.00231813
p_int:  0.834058484
p_ni:  0.165941516
Score:  0.189
Data Source:  BioPlex,STRINGDB
PLEKHA3
Tbio
Novelty:  0.06598909
Score:  0.816
Data Source:  STRINGDB
CPLX3
Tbio
Novelty:  0.07332857
Score:  0.8
Data Source:  STRINGDB
CTSA
Tchem
Family:  Enzyme
Novelty:  0.00170931
Score:  0.739
Data Source:  STRINGDB
GLTPD2
Tdark
Novelty:  4.03478767
Score:  0.685
Data Source:  STRINGDB
MDH1
Tchem
Family:  Enzyme
Novelty:  0.00203876
Score:  0.641
Data Source:  STRINGDB
CPTP
Tbio
Novelty:  0.06769635
Score:  0.619
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Glycosphingolipid metabolism (R-HSA-1660662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
38.2
hemoglobin measurement
1
1
1
36.9
platelet count
1
1
1
35
glomerular filtration rate
1
1
1
29
neutrophil count
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
38.2
hemoglobin measurement
1
36.9
platelet count
1
35
glomerular filtration rate
1
29
neutrophil count
1
11.2
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycolipid transfer protein
VGNC:13397
467126
Mouse
MGI:1929253
56356
Rat
RGD:1564442
288707
Horse
glycolipid transfer protein
VGNC:18396
100066526
Cow
glycolipid transfer protein
VGNC:50097
327678
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycolipid transfer protein
Mouse
Rat
Horse
glycolipid transfer protein
Cow
glycolipid transfer protein
Publication Statistics
PubMed Score 104.46
PubMed score by year
PubTator Score 38.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title