Tbio GLT8D2 Glycosyltransferase 8 domain-containing protein 2

Protein Summary

Uniprot Accession IDs

• Q9H1C3
• Q96KA2

Gene Name

• GLT8D2

Ensembl ID

• ENST00000360814
• ENSP00000354053
• ENSG00000120820
• ENST00000546436
• ENSP00000449750
• ENST00000548660
• ENSP00000447450

Symbol

• GALA4A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.61
histone modification site profile	0.59
virus perturbation	0.55
tissue sample	0.53
tissue	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.27   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.27   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (49)

Explore Interacting Targets

1 – 10 of 49

• See Interactions on String-DB

PSCA

Tbio

Novelty:  0.00323778

p_int:  0.999958753

p_ni:  0.000040889

p_wrong:  3.58e-7

Data Source:  BioPlex

CHRNA3

Tclin

Family:  IC

Novelty:  0.00659767

p_int:  0.999579184

p_ni:  0.000420812

p_wrong:  4e-9

Data Source:  BioPlex

CHRNB4

Tclin

Family:  IC

Novelty:  0.01151716

p_int:  0.999564623

p_ni:  0.00043236

p_wrong:  0.000003017

Data Source:  BioPlex

FUT1

Tbio

Family:  Enzyme

Novelty:  0.00597206

p_int:  0.998741657

p_ni:  0.000831545

p_wrong:  0.000426798

Score:  0.167

Data Source:  BioPlex,STRINGDB

MME

Tclin

Family:  Enzyme

Novelty:  0.00019144

p_int:  0.995822912

p_ni:  0.000605202

p_wrong:  0.003571886

Score:  0.175

Data Source:  BioPlex,STRINGDB

QSOX1

Tbio

Family:  Enzyme

Novelty:  0.02152583

p_int:  0.994746019

p_ni:  0.003266692

p_wrong:  0.001987289

Score:  0.201

Data Source:  BioPlex,STRINGDB

MGAT4C

Tdark

Family:  Enzyme

Novelty:  0.19680806

p_int:  0.988226502

p_ni:  0.006722108

p_wrong:  0.005051391

Data Source:  BioPlex

RMND1

Tbio

Novelty:  0.06181833

p_int:  0.953659749

p_ni:  0.046338571

p_wrong:  0.00000168

Data Source:  BioPlex

EIF2AK3

Tchem

Family:  Kinase

Novelty:  0.00044559

p_int:  0.907006967

p_ni:  0.092993031

p_wrong:  2e-9

Score:  0.163

Data Source:  BioPlex,STRINGDB

OSBPL8

Tbio

Novelty:  0.06812531

p_int:  0.895250802

p_ni:  0.104749198

Score:  0.167

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Functions (1)

Components (2)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
transferase activity, transferring glycosyl groups	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
central corneal thickness	EFO_0005213	2	2	0	3.2	88.3
heel bone mineral density	EFO_0009270	2	2	2		65.7
vascular cell adhesion molecule-1 measurement	EFO_0010057	1	1	1		61
intraocular pressure measurement	EFO_0004695	1	1	1		57.3
corneal topography	EFO_0004345	1	1	1		42.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
central corneal thickness	EFO_0005213	0	3.2	88.3
heel bone mineral density	EFO_0009270	2		65.7
vascular cell adhesion molecule-1 measurement	EFO_0010057	1		61
intraocular pressure measurement	EFO_0004695	1		57.3
corneal topography	EFO_0004345	1		42.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Glycoprotein
Glycosyltransferase
Membrane
Polymorphism
Reference proteome
Signal-anchor
Transferase
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
central corneal thickness
corneal topography
heel bone mineral density
intraocular pressure measurement
vascular cell adhesion molecule-1 measurement

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
immune system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	glycosyltransferase 8 domain containing 2	VGNC:5402	452189
Macaque	glycosyltransferase 8 domain containing 2		699937
Mouse	glycosyltransferase 8 domain containing 2	MGI:1922032	74782
Rat	glycosyltransferase 8 domain containing 2	RGD:1560432	366859
Dog	glycosyltransferase 8 domain containing 2	VGNC:41281	612239

Species	Name	OMA	EggNOG	Inparanoid
Chimp	glycosyltransferase 8 domain containing 2
Macaque	glycosyltransferase 8 domain containing 2
Mouse	glycosyltransferase 8 domain containing 2
Rat	glycosyltransferase 8 domain containing 2
Dog	glycosyltransferase 8 domain containing 2

Publication Statistics

PubMed Score 4.27

PubMed score by year

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PubTator Score 0.50

PubTator score by year

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Related Publications

Text Mined References (11)

GeneRif Annotations (4)

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10

0 of 0

PMID	Year	Title