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Tchem
GLS2
Glutaminase liver isoform, mitochondrial

Protein Summary
Description
Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in other tissues as well. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311966
  • ENSP00000310447
  • ENSG00000135423
  • ENST00000486896
  • ENSP00000419661

Symbol
  • GA
  • GA
  • GLS
  • LGA
  • hLGA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
histone modification site profile
0.83
cellular component
0.71
disease
0.64
small molecule perturbation
0.62


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 388.21   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 388.21   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (126)
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.98
Data Source:  STRINGDB
GLUL
Tchem
Family:  Enzyme
Novelty:  0.00086054
Score:  0.973
Data Source:  STRINGDB
GLUD1
Tbio
Family:  Enzyme
Novelty:  0.00301109
Score:  0.96
Data Source:  STRINGDB
ALDH4A1
Tbio
Family:  Enzyme
Novelty:  0.01316227
Score:  0.947
Data Source:  STRINGDB
GAD1
Tbio
Family:  Enzyme
Novelty:  0.00067443
Score:  0.941
Data Source:  STRINGDB
GLUD2
Tbio
Family:  Enzyme
Novelty:  0.01470266
Score:  0.939
Data Source:  STRINGDB
CAD
Tchem
Novelty:  0.00651422
Score:  0.938
Data Source:  STRINGDB
GAD2
Tbio
Family:  Enzyme
Novelty:  0.00058427
Score:  0.937
Data Source:  STRINGDB
PPAT
Tclin
Family:  Enzyme
Novelty:  0.01549862
Score:  0.931
Data Source:  STRINGDB
GFPT1
Tchem
Family:  Enzyme
Novelty:  0.00358283
Score:  0.927
Data Source:  STRINGDB
Pathways (27)
Gene expression (Transcription) (R-HSA-74160)

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Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Glutamate Neurotransmitter Release Cycle
Reactome
Glutamate and glutamine metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Glutamate Neurotransmitter Release Cycle
Glutamate and glutamine metabolism
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
4
3
7
96.9
metabolite measurement
2
2
2
91.1
blood metabolite measurement
4
2
5
89.2
protein measurement
1
1
1
86.2
serum metabolite measurement
3
1
3
81.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
7
96.9
metabolite measurement
2
91.1
blood metabolite measurement
5
89.2
protein measurement
1
86.2
serum metabolite measurement
3
81.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutaminase 2
VGNC:5401
451998
Macaque
glutaminase 2
712962
Mouse
MGI:2143539
216456
Rat
RGD:620359
192268
Dog
glutaminase 2
VGNC:41277
100686499
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutaminase 2
Macaque
glutaminase 2
Mouse
Rat
Dog
glutaminase 2
Publication Statistics
PubMed Score 388.21
PubMed score by year
PubTator Score 106.09
PubTator score by year
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Related Publications
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PMID
Year
Title