Tchem GLS Glutaminase kidney isoform, mitochondrial

Protein Summary

Description

Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• O94925
• Q9UL05
• Q9UL06
• Q9UL07
• Q9UN40
• GLS

Gene Name

• GLS

Ensembl ID

• ENST00000320717
• ENSP00000317379
• ENSG00000115419
• ENST00000338435
• ENSP00000340689

Symbol

• GLS1
• KIAA0838
• GAC
• GAM
• KGA
• GLS1
• AAD20
• CASGID
• EIEE71

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
transcription factor perturbation	0.98
small molecule perturbation	0.9
transcription factor binding site profile	0.85
kinase perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Hydrolase / Glutaminase Kidney Isoform, Mitochondrial

DTO Classes

Protein / Enzyme / Hydrolase / Glutaminase Kidney Isoform, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 354.45   (req: < 5)

Gene RIFs: 62   (req: <= 3)

Antibodies: 392   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 354.45   (req: >= 5)

Gene RIFs: 62   (req: > 3)

Antibodies: 392   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 596

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (596)

Explore Active Ligands

1 – 10 of 596

CHEMBL4082885

GLSTchem Enzyme

pIC50 : 7.46

CHEMBL4090687

GLSTchem Enzyme

pIC50 : 7.35

CHEMBL4061000

GLSTchem Enzyme

pIC50 : 7.32

CHEMBL4080388

GLSTchem Enzyme

pIC50 : 7.31

CB-839

GLSTchem Enzyme

pKd : 7.04

CHEMBL4538736

GLSTchem Enzyme

pIC50 : 10

CHEMBL4547874

GLSTchem Enzyme

pIC50 : 9.7

CHEMBL3810168

GLSTchem Enzyme

pIC50 : 9.69

CHEMBL3810394

GLSTchem Enzyme

pIC50 : 9.41

CHEMBL3809014

GLSTchem Enzyme

pIC50 : 9.4

Protein-Protein Interactions (154)

Explore Interacting Targets

1 – 10 of 154

• See Interactions on String-DB

COL20A1

Tdark

Novelty:  0.39788946

p_int:  0.999995342

p_ni:  0.000004658

p_wrong:  1e-9

Data Source:  BioPlex

PI15

Tbio

Family:  Enzyme

Novelty:  0.02244161

p_int:  0.999961534

p_ni:  0.000038466

Data Source:  BioPlex

CCL22

Tbio

Novelty:  0.00245992

p_int:  0.995906026

p_ni:  0.004093974

Data Source:  BioPlex

NDUFS7

Tclin

Family:  Enzyme

Novelty:  0.01562198

p_int:  0.990357956

p_ni:  0.00964103

p_wrong:  0.000001014

Score:  0.15

Data Source:  BioPlex,STRINGDB

HMGCL

Tbio

Family:  Enzyme

Novelty:  0.02741994

p_int:  0.974574539

p_ni:  0.025425443

p_wrong:  1.8e-8

Score:  0.163

Data Source:  BioPlex,STRINGDB

SNRNP27

Tbio

Novelty:  0.0175187

p_int:  0.971506223

p_ni:  0.028493777

Data Source:  BioPlex

CFAP45

Tbio

Novelty:  0.12173319

p_int:  0.965273245

p_ni:  0.034726755

Score:  0.416

Data Source:  BioPlex,STRINGDB

TRMT61B

Tbio

Family:  Enzyme

Novelty:  0.32929047

p_int:  0.922051708

p_ni:  0.077948292

p_wrong:  1e-9

Score:  0.181

Data Source:  BioPlex,STRINGDB

TNF

Tclin

Novelty:  0.00001457

p_int:  0.914274149

p_ni:  0.08572584

p_wrong:  1.1e-8

Score:  0.36

Data Source:  BioPlex,STRINGDB

MRPL43

Tdark

Novelty:  0.22331841

p_int:  0.90434402

p_ni:  0.095655887

p_wrong:  9.4e-8

Score:  0.232

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (3)

Explore Nearest Tclin Targets

Upstream (2)

Downstream (1)

1 – 2 of 2

CPS1

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  3

1: Alanine, aspartate and glutamate metabolism

2: Metabolic pathways

3: Arginine biosynthesis

PPAT

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  2

1: Alanine, aspartate and glutamate metabolism

2: Metabolic pathways

Pathways (25)

Reactome (12)

KEGG (9)

PathwayCommons (2)

WikiPathways (2)

Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 12

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	Glutamate Neurotransmitter Release Cycle	24 targets	R-HSA-210500
Reactome	Glutamate and glutamine metabolism	13 targets	R-HSA-8964539
Reactome	Metabolism	2112 targets	R-HSA-1430728

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
Glutamate Neurotransmitter Release Cycle	24 targets	R-HSA-210500
Glutamate and glutamine metabolism	13 targets	R-HSA-8964539
Metabolism	2112 targets	R-HSA-1430728

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (1)

Components (3)

Processes (8)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
glutaminase activity	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (14)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 14

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3	4	4		92.8
reticulocyte count	EFO_0007986	7	3	7		88.9
systemic scleroderma	EFO_0000717	3	2	0	1.3	87.4
reticulocyte measurement	EFO_0010700	3	2	3		79.2
birth weight	EFO_0004344	2	2	2		57.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 14

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	4		92.8
reticulocyte count	EFO_0007986	7		88.9
systemic scleroderma	EFO_0000717	0	1.3	87.4
reticulocyte measurement	EFO_0010700	3		79.2
birth weight	EFO_0004344	2		57.1

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
ANK repeat
Complete proteome
Cytoplasm
Direct protein sequencing
Hydrolase
Mitochondrion
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
birth weight
BMI-adjusted waist-hip ratio
body height
celiac disease
JT interval
mean platelet volume
neutrophil percentage of granulocytes
response to sulfonylurea
reticulocyte count
reticulocyte measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
mortality/aging
nervous system phenotype
respiratory system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	glutaminase	VGNC:443	470606
Mouse	glutaminase	MGI:95752	14660
Rat	glutaminase	RGD:2707	24398
Dog	glutaminase	VGNC:41276	488448
Horse	glutaminase [Source:HGNC Symbol;Acc:HGNC:4331]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	glutaminase
Mouse	glutaminase
Rat	glutaminase
Dog	glutaminase
Horse	glutaminase [Source:HGNC Symbol;Acc:HGNC:4331]

Publication Statistics

PubMed Score 354.45

PubMed score by year

Reset Zoom

PubTator Score 180.55

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (87)

GeneRif Annotations (62)

Items per page:

10

0 of 0

PMID	Year	Title