Tchem GLS Glutaminase kidney isoform, mitochondrial

Protein Summary

Description

Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• O94925
• Q9UL05
• Q9UL06
• Q9UL07
• Q9UN40
• GLS

Gene Name

• GLS

Ensembl ID

• ENST00000320717
• ENSP00000317379
• ENSG00000115419
• ENST00000338435
• ENSP00000340689

Symbol

• GLS1
• KIAA0838
• GAC
• GAM
• KGA
• GLS1
• AAD20
• CASGID
• EIEE71

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
transcription factor perturbation	0.98
small molecule perturbation	0.9
transcription factor binding site profile	0.85
kinase perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Hydrolase / Glutaminase Kidney Isoform, Mitochondrial

DTO Classes

Protein / Enzyme / Hydrolase / Glutaminase Kidney Isoform, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 446.88   (req: < 5)

Gene RIFs: 62   (req: <= 3)

Antibodies: 392   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 446.88   (req: >= 5)

Gene RIFs: 62   (req: > 3)

Antibodies: 392   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 644

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0