Protein Summary
Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants hav ...more
- ENST00000331244
- ENSP00000330836
- ENSG00000108010
- ENST00000368644
- ENSP00000357633
- ENST00000481034
- ENSP00000435445
- PICOT
- TXNL2
- GRX3
- GRX4
- GLRX4
- PICOT
- TXNL2
- TXNL3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.91 | ||
transcription factor perturbation | 0.8 | ||
disease perturbation | 0.79 | ||
molecular function | 0.79 | ||
transcription factor | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 124.38 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 330 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 124.38 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 330 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (131)
CIAPIN1
Novelty: 0.01359005
p_int: 0.999997386
p_ni: 0.000002614
Score: 0.995
Data Source: BioPlex,STRINGDB
BOLA1
Novelty: 0.1092583
p_int: 0.999995025
p_ni: 0.000004975
Score: 0.98
Data Source: BioPlex,STRINGDB
RGS20
Novelty: 0.04087618
p_int: 0.999993154
p_ni: 0.000006846
Score: 0.445
Data Source: BioPlex,STRINGDB
RRM1
Family: Enzyme
Novelty: 0.00083196
p_int: 0.999990513
p_ni: 0.000009487
Score: 0.311
Data Source: BioPlex,STRINGDB
KLRG2
Novelty: 1.19446694
p_int: 0.999965695
p_ni: 0.000034305
Score: 0.455
Data Source: BioPlex,STRINGDB
NDOR1
Family: Enzyme
Novelty: 0.07400532
p_int: 0.979438283
p_ni: 0.020561717
Score: 0.585
Data Source: BioPlex,STRINGDB
SRC
Family: Kinase
Novelty: 0.00008479
p_int: 0.929896251
p_ni: 0.070093172
p_wrong: 0.000010577
Data Source: BioPlex
NAA40
Family: Enzyme
Novelty: 0.13882523
p_int: 0.884316784
p_ni: 0.115683216
Score: 0.193
Data Source: BioPlex,STRINGDB
GNAZ
Novelty: 0.02008523
p_int: 0.7958059
p_ni: 0.189972379
p_wrong: 0.014221721
Score: 0.159
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (2)
Reactome (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Iron uptake and transport | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Iron uptake and transport | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (8)
Components (5)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glutaredoxin 3 | VGNC:3867 | 450828 | |||||
Macaque | glutaredoxin 3 | 698891 | ||||||
Mouse | MGI:1353653 | 30926 | ||||||
Rat | RGD:69414 | 58815 | ||||||
Dog | glutaredoxin 3 | VGNC:41275 | 477869 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | glutaredoxin 3 | |||||
Macaque | glutaredoxin 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | glutaredoxin 3 | |||||
Publication Statistics
PubMed Score 124.38
PubMed score by year
PubTator Score 52.38
PubTator score by year
Related Publications
Text Mined References (41)
GeneRif Annotations (18)
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