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Tbio
GLRX
Glutaredoxin-1

Protein Summary
Description
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237858
  • ENSP00000237858
  • ENSG00000173221
  • ENST00000379979
  • ENSP00000369314
  • ENST00000505427
  • ENSP00000427353
  • ENST00000508780
  • ENSP00000422708
  • ENST00000512469
  • ENSP00000424636

Symbol
  • GRX
  • GRX
  • GRX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
PubMedID
0.99
kinase perturbation
0.96
small molecule perturbation
0.96
disease perturbation
0.95


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 970.82   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 970.82   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (163)
CFAP298
Tbio
Novelty:  0.1550579
p_int:  0.999939183
p_ni:  0.000015962
p_wrong:  0.000044855
Score:  0.303
Data Source:  BioPlex,STRINGDB
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.987836214
p_ni:  0.006392739
p_wrong:  0.005771046
Data Source:  BioPlex
IGHA2
Tbio
p_int:  0.971705536
p_ni:  0.02827784
p_wrong:  0.000016623
Data Source:  BioPlex
LTF
Tbio
Novelty:  0.00114254
p_int:  0.914486878
p_ni:  0.085513122
Data Source:  BioPlex
PFN3
Tdark
Novelty:  0.11291078
p_int:  0.90385693
p_ni:  0.086043241
p_wrong:  0.010099829
Data Source:  BioPlex
LYRM7
Tbio
Novelty:  0.16270565
p_int:  0.86261421
p_ni:  0.109878658
p_wrong:  0.027507131
Score:  0.209
Data Source:  BioPlex,STRINGDB
PYY
Tbio
Novelty:  0.00060997
p_int:  0.86261421
p_ni:  0.109878658
p_wrong:  0.027507131
Data Source:  BioPlex
MRPS12
Tbio
Novelty:  0.15394123
p_int:  0.86261421
p_ni:  0.109878658
p_wrong:  0.027507131
Data Source:  BioPlex
HPRT1
Tchem
Family:  Enzyme
Novelty:  0.00032232
p_int:  0.83845468
p_ni:  0.16154532
Data Source:  BioPlex
CHURC1
Tbio
Novelty:  0.05885372
p_int:  0.757488791
p_ni:  0.008064526
p_wrong:  0.234446684
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
3
14
95.9
reticulocyte measurement
3
2
6
89.4
FEV/FEC ratio
1
1
1
79.9
serum non-albumin protein measurement
2
2
2
78.3
1
1
0
1.2
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
14
95.9
reticulocyte measurement
6
89.4
FEV/FEC ratio
1
79.9
serum non-albumin protein measurement
2
78.3
0
1.2
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutaredoxin
VGNC:4016
736317
Macaque
glutaredoxin
698997
Mouse
MGI:2135625
93692
Rat
RGD:70951
64045
Dog
glutaredoxin
VGNC:41273
609246
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutaredoxin
Macaque
glutaredoxin
Mouse
Rat
Dog
glutaredoxin
Publication Statistics
PubMed Score 970.82
PubMed score by year
PubTator Score 335.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title