GLRA2
Glycine receptor subunit alpha-2
Protein Summary
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467). The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
- ENST00000218075
- ENSP00000218075
- ENSG00000101958
- ENST00000355020
- ENSP00000347123
- ENST00000443437
- ENSP00000387756
- GLR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.99 | ||
molecular function | 0.96 | ||
protein domain | 0.92 | ||
ligand (chemical) | 0.72 | ||
trait | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 63.83 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 45 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 63.83 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 45 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 20
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 5