Tclin GLP2R Glucagon-like peptide 2 receptor

Protein Summary

Description

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• O95838
• Q4VAT3
• GLP-2 receptor

Gene Name

• GLP2R

Ensembl ID

• ENST00000262441
• ENSP00000262441
• ENSG00000065325

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.63
protein domain	0.58
disease	0.53
tissue sample	0.51
phenotype	0.42

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class B Secretin Like / Glucagon Receptor / Glucagon-like Peptide 2 Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.53   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 349   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.53   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 349   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 85

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1