Protein Summary
Isoform 1: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes (PubMed:22405651, PubMed:22748924). Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34 (PubMed:22405651, PubMed:22748924). Inhibits RBX1-mediated neddylation of CUL1 (PubMed:22405651). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity). Essential for normal development of the vasculature (PubMed:11845407). Contributes to the regulation of RPS6KB1 phosphorylation (PubMed:11571281). This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been a ...more
- ENST00000370360
- ENSP00000359385
- ENSG00000174842
- ENST00000495106
- ENSP00000436829
- FAP48
- FAP68
- VMGLOM
- FAP
- GVM
- GLML
- FAP48
- FAP68
- FKBPAP
- VMGLOM
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.93 | ||
biological process | 0.81 | ||
cell type or tissue | 0.67 | ||
interacting protein | 0.62 | ||
tissue sample | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 52.37 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 230 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 52.37 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 230 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (362)
CUL7
Novelty: 0.02183958
p_int: 0.999999796
p_ni: 2.04e-7
Score: 0.984
Data Source: BioPlex,STRINGDB
CUL9
Novelty: 0.1104365
p_int: 0.999999694
p_ni: 3.05e-7
Score: 0.485
Data Source: BioPlex,STRINGDB
ZSWIM6
Novelty: 0.20377569
p_int: 0.999999469
p_ni: 1e-9
p_wrong: 5.3e-7
Score: 0.237
Data Source: BioPlex,STRINGDB
ANKLE2
Novelty: 0.0995907
p_int: 0.999994936
p_ni: 0.000005049
p_wrong: 1.5e-8
Score: 0.16
Data Source: BioPlex,STRINGDB
TMEM143
Novelty: 1.58941369
p_int: 0.999971456
p_ni: 0.00002802
p_wrong: 5.25e-7
Data Source: BioPlex
APPBP2
Novelty: 0.14742368
p_int: 0.999939066
p_ni: 0.000060876
p_wrong: 5.8e-8
Data Source: BioPlex
NT5E
Family: Enzyme
Novelty: 0.00083237
p_int: 0.999935766
p_ni: 0.000064234
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Class I MHC mediated antigen processing & presentation | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (3)
Components (6)
Processes (9)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Genetic Interaction (IGI) | MGI | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 2 | 5 | 6 | 98.9 | |||||
monocyte count | 1 | 2 | 2 | 95.7 | |||||
granulocyte percentage of myeloid white cells | 1 | 2 | 2 | 95 | |||||
3 | 3 | 0 | 1.2 | 91.6 | |||||
lymphocyte percentage of leukocytes | 2 | 2 | 2 | 83.1 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 6 | 98.9 | |||||
monocyte count | 2 | 95.7 | |||||
granulocyte percentage of myeloid white cells | 2 | 95 | |||||
0 | 1.2 | 91.6 | |||||
lymphocyte percentage of leukocytes | 2 | 83.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | glomulin, FKBP associated protein | VGNC:8326 | 457020 | |||||
Macaque | glomulin, FKBP associated protein | 706249 | ||||||
Mouse | MGI:2141180 | 170823 | ||||||
Rat | RGD:1588600 | 289437 | ||||||
Dog | glomulin, FKBP associated protein | VGNC:41264 | 479951 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | glomulin, FKBP associated protein | |||||
Macaque | glomulin, FKBP associated protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | glomulin, FKBP associated protein | |||||
Publication Statistics
PubMed Score 52.37
PubMed score by year
PubTator Score 31.01
PubTator score by year
Related Publications
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Text |
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