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Tbio
GLMN
Glomulin

Protein Summary
Description
Isoform 1: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes (PubMed:22405651, PubMed:22748924). Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34 (PubMed:22405651, PubMed:22748924). Inhibits RBX1-mediated neddylation of CUL1 (PubMed:22405651). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity). Essential for normal development of the vasculature (PubMed:11845407). Contributes to the regulation of RPS6KB1 phosphorylation (PubMed:11571281). This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370360
  • ENSP00000359385
  • ENSG00000174842
  • ENST00000495106
  • ENSP00000436829

Symbol
  • FAP48
  • FAP68
  • VMGLOM
  • FAP
  • GVM
  • GLML
  • FAP48
  • FAP68
  • FKBPAP
  • VMGLOM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
biological process
0.81
cell type or tissue
0.67
interacting protein
0.62
tissue sample
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.37   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.37   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (362)
CUL7
Tbio
Novelty:  0.02183958
p_int:  0.999999796
p_ni:  2.04e-7
Score:  0.984
Data Source:  BioPlex,STRINGDB
CUL9
Tbio
Novelty:  0.1104365
p_int:  0.999999694
p_ni:  3.05e-7
Score:  0.485
Data Source:  BioPlex,STRINGDB
ZSWIM6
Tbio
Novelty:  0.20377569
p_int:  0.999999469
p_ni:  1e-9
p_wrong:  5.3e-7
Score:  0.237
Data Source:  BioPlex,STRINGDB
ANKLE2
Tbio
Novelty:  0.0995907
p_int:  0.999994936
p_ni:  0.000005049
p_wrong:  1.5e-8
Score:  0.16
Data Source:  BioPlex,STRINGDB
FEM1B
Tbio
Novelty:  0.06746412
p_int:  0.999978942
p_ni:  0.000021058
Data Source:  BioPlex
TMEM143
Tdark
Novelty:  1.58941369
p_int:  0.999971456
p_ni:  0.00002802
p_wrong:  5.25e-7
Data Source:  BioPlex
KLHDC3
Tdark
Novelty:  0.63840156
p_int:  0.999958805
p_ni:  0.000041195
Data Source:  BioPlex
APPBP2
Tbio
Novelty:  0.14742368
p_int:  0.999939066
p_ni:  0.000060876
p_wrong:  5.8e-8
Data Source:  BioPlex
NT5E
Tchem
Family:  Enzyme
Novelty:  0.00083237
p_int:  0.999935766
p_ni:  0.000064234
Data Source:  BioPlex
ARRDC1
Tbio
Novelty:  0.10481621
p_int:  0.999906896
p_ni:  0.000093104
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
5
6
98.9
monocyte count
1
2
2
95.7
granulocyte percentage of myeloid white cells
1
2
2
95
3
3
0
1.2
91.6
lymphocyte percentage of leukocytes
2
2
2
83.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
6
98.9
monocyte count
2
95.7
granulocyte percentage of myeloid white cells
2
95
0
1.2
91.6
lymphocyte percentage of leukocytes
2
83.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glomulin, FKBP associated protein
VGNC:8326
457020
Macaque
glomulin, FKBP associated protein
706249
Mouse
MGI:2141180
170823
Rat
RGD:1588600
289437
Dog
glomulin, FKBP associated protein
VGNC:41264
479951
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glomulin, FKBP associated protein
Macaque
glomulin, FKBP associated protein
Mouse
Rat
Dog
glomulin, FKBP associated protein
Publication Statistics
PubMed Score 52.37
PubMed score by year
PubTator Score 31.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text