Protein Summary
Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). Isoform 1, isoform 2, isoform 3 and isoform 4: Act as transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Bind to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). Are involved in the smoothened (SHH) signaling pathway (PubMed:18455992). Isoform 5: Acts as a transcriptional repressor. This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are ...more
- ENST00000361492
- ENSP00000354586
- ENSG00000074047
- ENST00000452319
- ENSP00000390436
- THP
- CJS
- HPE9
- PHS2
- THP1
- THP2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
hub protein | 0.94 | ||
PubMedID | 0.74 | ||
disease | 0.73 | ||
cell type or tissue | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 432.01 (req: < 5)
Gene RIFs: 119 (req: <= 3)
Antibodies: 285 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 432.01 (req: >= 5)
Gene RIFs: 119 (req: > 3)
Antibodies: 285 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 59
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (255)
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (42)
Reactome (12)
KEGG (4)
PathwayCommons (8)
WikiPathways (18)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Degradation of GLI2 by the proteasome | ||||
Reactome | GLI proteins bind promoters of Hh responsive genes to promote transcription | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Hedgehog 'off' state | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Degradation of GLI2 by the proteasome | ||||
GLI proteins bind promoters of Hh responsive genes to promote transcription | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Hedgehog 'off' state | ||||
Viral Interactions (0)
Gene Ontology Terms (70)
Functions (8)
Components (11)
Processes (51)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body height | 1 | 2 | 2 | 82.8 | |||||
sex hormone-binding globulin measurement | 2 | 1 | 2 | 65.3 | |||||
BMI-adjusted waist circumference | 2 | 2 | 2 | 55.8 | |||||
balding measurement | 1 | 2 | 2 | 55.8 | |||||
1 | 1 | 0 | 1.1 | 4.5 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body height | 2 | 82.8 | |||||
sex hormone-binding globulin measurement | 2 | 65.3 | |||||
BMI-adjusted waist circumference | 2 | 55.8 | |||||
balding measurement | 2 | 55.8 | |||||
0 | 1.1 | 4.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | GLI family zinc finger 2 | VGNC:442 | 459582 | |||||
Macaque | GLI family zinc finger 2 | 705877 | ||||||
Mouse | MGI:95728 | 14633 | ||||||
Rat | RGD:1309270 | 304729 | ||||||
Dog | GLI family zinc finger 2 | VGNC:41257 | 100682984 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | GLI family zinc finger 2 | |||||
Macaque | GLI family zinc finger 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | GLI family zinc finger 2 | |||||
Publication Statistics
PubMed Score 432.01
PubMed score by year
PubTator Score 3183.05
PubTator score by year
Related Publications
Text Mined References (148)
GeneRif Annotations (119)
Items per page:
0 of 0
PMID | Year | Title |
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