Tbio GLE1 Nucleoporin GLE1

Protein Summary

Description

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q53GS7
• O75458
• Q53GT9
• Q5VVU1
• Q8NCP6
• Q9UFL6
• hGLE1

Gene Name

• GLE1

Ensembl ID

• ENST00000309971
• ENSP00000308622
• ENSG00000119392
• ENST00000372770
• ENSP00000361856

Symbol

• GLE1L
• LCCS
• CAAHC
• CAAHD
• GLE1L
• LCCS1
• hGLE1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
transcription factor perturbation	0.84
histone modification site profile	0.83
kinase perturbation	0.76
tissue	0.66

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Nucleoporin Gle1

Protein / Nucleic Acid Binding / Nucleoporin Gle1

DTO Classes

Protein / Transporter / Nucleoporin Gle1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.44   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 191   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.44   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0