You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GLDC
Glycine dehydrogenase (decarboxylating), mitochondrial

Protein Summary
Description
The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH). Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321612
  • ENSP00000370737
  • ENSG00000178445

Symbol
  • GCSP
  • GCE
  • GCSP
  • HYGN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
PubMedID
0.9
protein domain
0.85
transcription factor perturbation
0.68
histone modification site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.45   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.45   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
SEMA3E
Tbio
Novelty:  0.00936004
p_int:  0.999117492
p_ni:  0.000882508
Data Source:  BioPlex
GCSH
Tbio
Novelty:  0.02101972
p_int:  0.997803474
p_ni:  0.002196526
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ANKRD39
Tdark
Novelty:  8.68843298
p_int:  0.996212607
p_ni:  0.00378729
p_wrong:  1.03e-7
Data Source:  BioPlex
NDUFAB1
Tclin
Novelty:  0.00190242
p_int:  0.993084947
p_ni:  0.006915053
Score:  0.369
Data Source:  BioPlex,STRINGDB
SEMA3B
Tbio
Novelty:  0.00626976
p_int:  0.965691067
p_ni:  0.034308856
p_wrong:  7.7e-8
Data Source:  BioPlex
SPATA13
Tbio
Novelty:  0.19610601
p_int:  0.957971573
p_ni:  0.042028427
Score:  0.214
Data Source:  BioPlex,STRINGDB
SOST
Tclin
Novelty:  0.0009273
p_int:  0.957812141
p_ni:  0.042187859
Score:  0.171
Data Source:  BioPlex,STRINGDB
POLG2
Tbio
Family:  Enzyme
Novelty:  0.0233323
p_int:  0.94291368
p_ni:  0.05708632
Score:  0.214
Data Source:  BioPlex,STRINGDB
CAPN6
Tbio
Novelty:  0.04489237
p_int:  0.872686946
p_ni:  0.127312853
p_wrong:  2.01e-7
Score:  0.244
Data Source:  BioPlex,STRINGDB
FDPS
Tclin
Family:  Enzyme
Novelty:  0.00164195
p_int:  0.845079644
p_ni:  0.154920356
Score:  0.241
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Glycine degradation (R-HSA-6783984)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycine degradation
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Glycine degradation
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
7
89.3
glycine measurement
1
1
1
82.6
1
2
0
1.1
81.6
urinary metabolite measurement
1
1
1
37.6
1
1
0
1.9
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
7
89.3
glycine measurement
1
82.6
0
1.1
81.6
urinary metabolite measurement
1
37.6
0
1.9
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycine decarboxylase
VGNC:8826
464987
Macaque
glycine decarboxylase
715563
Mouse
MGI:1341155
104174
Rat
RGD:1308660
309312
Dog
glycine decarboxylase
VGNC:41252
481534
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycine decarboxylase
Macaque
glycine decarboxylase
Mouse
Rat
Dog
glycine decarboxylase
Publication Statistics
PubMed Score 124.45
PubMed score by year
PubTator Score 106.60
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title