Tbio GLDC Glycine dehydrogenase (decarboxylating), mitochondrial

Protein Summary

Description

The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH). Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• P23378
• Q2M2F8

Gene Name

• GLDC

Ensembl ID

• ENST00000321612
• ENSP00000370737
• ENSG00000178445

Symbol

• GCSP
• GCE
• GCSP
• HYGN1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.97
PubMedID	0.9
protein domain	0.85
transcription factor perturbation	0.68
histone modification site profile	0.67

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / Glycine Dehydrogenase (Decarboxylating), Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Glycine Dehydrogenase (Decarboxylating), Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.02   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 180   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.02   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0