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Tbio
GLCE
D-glucuronyl C5-epimerase

Protein Summary
Description
Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261858
  • ENSP00000261858
  • ENSG00000138604

Symbol
  • KIAA0836
  • HSEPI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
microRNA
0.74
PubMedID
0.7
tissue sample
0.66
pathway
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.34   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.34   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.999987728
p_ni:  0.000012258
p_wrong:  1.4e-8
Data Source:  BioPlex
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.999984485
p_ni:  0.000015514
p_wrong:  1e-9
Data Source:  BioPlex
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.999972125
p_ni:  0.00002787
p_wrong:  4e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
HAUS7
Tbio
Novelty:  1.11657571
p_int:  0.999872627
p_ni:  0.000108014
p_wrong:  0.000019359
Score:  0.173
Data Source:  BioPlex,STRINGDB
SDC2
Tbio
Novelty:  0.00597758
Score:  0.968
Data Source:  STRINGDB
GPC4
Tbio
Novelty:  0.01319626
Score:  0.967
Data Source:  STRINGDB
GPC6
Tbio
Novelty:  0.01951872
Score:  0.964
Data Source:  STRINGDB
GPC2
Tbio
Novelty:  0.02182363
Score:  0.961
Data Source:  STRINGDB
GPC1
Tbio
Novelty:  0.00293087
Score:  0.959
Data Source:  STRINGDB
GPC3
Tbio
Novelty:  0.00151823
Score:  0.954
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Glycosaminoglycan metabolism (R-HSA-1630316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
HS-GAG biosynthesis
Reactome
Heparan sulfate/heparin (HS-GAG) metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
HS-GAG biosynthesis
Heparan sulfate/heparin (HS-GAG) metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
2
2
67.5
basophil percentage of leukocytes
1
1
1
59
lymphocyte count
1
1
1
44.2
calcium measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
67.5
basophil percentage of leukocytes
1
59
lymphocyte count
1
44.2
calcium measurement
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucuronic acid epimerase
VGNC:3549
453542
Macaque
glucuronic acid epimerase
694999
Mouse
MGI:2136405
93683
Rat
RGD:1565253
363073
Dog
glucuronic acid epimerase
VGNC:41251
487622
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucuronic acid epimerase
Macaque
glucuronic acid epimerase
Mouse
Rat
Dog
glucuronic acid epimerase
Publication Statistics
PubMed Score 27.34
PubMed score by year
PubTator Score 18.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title