Tdark GLB1L3 Beta-galactosidase-1-like protein 3

Protein Summary

Uniprot Accession IDs

• Q8NCI6
• A6NEM0
• A6NN15
• Q6P3S3
• Q96FF8

Gene Name

• GLB1L3

Ensembl ID

• ENST00000389887
• ENSP00000374537
• ENSG00000166105
• ENST00000431683
• ENSP00000396615

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
gene perturbation	0.68
cell type or tissue	0.56
histone modification site profile	0.5
microRNA	0.47

Protein Classes

PANTHER Classes

Protein / Hydrolase / Galactosidase / Beta-galactosidase-1-like Protein 3

DTO Classes

Protein / Enzyme / Hydrolase / Galactosidase / Beta-galactosidase-1-like Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.11   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 115   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.11   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (48)

Explore Interacting Targets

1 – 10 of 48

• See Interactions on String-DB

NARS2

Tbio

Family:  Enzyme

Novelty:  0.01879317

p_int:  0.999631921

p_ni:  0.000368005

p_wrong:  7.4e-8

Data Source:  BioPlex

NDUFAF7

Tbio

Family:  Enzyme

Novelty:  0.24691414

p_int:  0.999593732

p_ni:  0.000406268

Data Source:  BioPlex

POLG

Tchem

Family:  Enzyme

Novelty:  0.00172189

p_int:  0.999277175

p_ni:  0.000722825

Score:  0.167

Data Source:  BioPlex,STRINGDB

GFM2

Tbio

Novelty:  0.02945848

p_int:  0.998787891

p_ni:  0.001209264

p_wrong:  0.000002845

Data Source:  BioPlex

MTIF2

Tbio

Novelty:  0.06681774

p_int:  0.994517064

p_ni:  0.005482936

Data Source:  BioPlex

D2HGDH

Tbio

Family:  Enzyme

Novelty:  0.04618268

p_int:  0.993870203

p_ni:  0.006007331

p_wrong:  0.000122467

Data Source:  BioPlex

SEPT1

Tdark

Novelty:  0.04450119

p_int:  0.991217417

p_ni:  0.001661328

p_wrong:  0.007121255

Data Source:  BioPlex

GATB

Tbio

Family:  Enzyme

Novelty:  0.01269151

p_int:  0.982146456

p_ni:  0.017847955

p_wrong:  0.000005589

Data Source:  BioPlex

NUDT19

Tdark

Novelty:  0.26928757

p_int:  0.963412382

p_ni:  0.032679123

p_wrong:  0.003908495

Data Source:  BioPlex

CPS1

Tclin

Family:  Enzyme

Novelty:  0.00917469

p_int:  0.962071607

p_ni:  0.037928393

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

PathwayCommons (1)

Find Similar Targets

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: humancyc	lactose degradation III	2 targets	PathwayCommons: humancyc

Name	Explore in Pharos	Explore in Source
lactose degradation III	2 targets	PathwayCommons: humancyc

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Functions (1)

Components (1)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
beta-galactosidase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	2	2	1	8.9	89
insomnia measurement	EFO_0007876	1	1	0	1.1	26.6
N-glycan measurement	EFO_0004999	1	1	1		21.5
age at first sexual intercourse measurement	EFO_0009749	1	1	1		15.8
prostate carcinoma	EFO_0001663	1	1	0	1.1	14.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	1	8.9	89
insomnia measurement	EFO_0007876	0	1.1	26.6
N-glycan measurement	EFO_0004999	1		21.5
age at first sexual intercourse measurement	EFO_0009749	1		15.8
prostate carcinoma	EFO_0001663	0	1.1	14.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Glycosidase
Hydrolase
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
age at first sexual intercourse measurement
alkaline phosphatase measurement
insomnia measurement
N-glycan measurement
prostate carcinoma

IDG Resources

No IDG generated resources found

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	galactosidase beta 1 like 3	VGNC:3267	747328
Mouse	galactosidase, beta 1 like 3	MGI:1918143	70893
Rat	galactosidase, beta 1-like 3	RGD:1561462	500961
Dog	galactosidase beta 1 like 3	VGNC:49807	489267
Horse	galactosidase beta 1 like 3 [Source:HGNC Symbol;Acc:HGNC:25147]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	galactosidase beta 1 like 3
Mouse	galactosidase, beta 1 like 3
Rat	galactosidase, beta 1-like 3
Dog	galactosidase beta 1 like 3
Horse	galactosidase beta 1 like 3 [Source:HGNC Symbol;Acc:HGNC:25147]

Publication Statistics

PubMed Score 1.11

PubMed score by year

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Related Publications

Text Mined References (8)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title