Tchem GLB1 Beta-galactosidase

Protein Summary

Description

Isoform 1: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Isoform 2: Has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers. This gene encodes a member of the glycosyl hydrolase 35 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature lysosomal enzyme. This enzyme catalyzes the hydrolysis of a terminal beta-linked galactose residue from ganglioside substrates and other glycoconjugates. Mutations in this gene may result in GM1-gangliosidosis and Morquio B syndrome. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P16278
• B2R7H8
• B7Z6B0
• P16279

Gene Name

• GLB1

Ensembl ID

• ENST00000307363
• ENSP00000306920
• ENSG00000170266
• ENST00000399402
• ENSP00000382333
• ENST00000445488
• ENSP00000393377

Symbol

• ELNR1
• EBP
• ELNR1
• MPS4B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
protein domain	0.85
disease perturbation	0.83
cellular component	0.79
histone modification site profile	0.76

Protein Classes

PANTHER Classes

Protein / Hydrolase / Galactosidase / Beta-galactosidase

DTO Classes

Protein / Enzyme / Hydrolase / Galactosidase / Beta-galactosidase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 428.72   (req: < 5)

Gene RIFs: 62   (req: <= 3)

Antibodies: 607   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 428.72   (req: >= 5)

Gene RIFs: 62   (req: > 3)

Antibodies: 607   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0