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Tchem
GLB1
Beta-galactosidase

Protein Summary
Description
Isoform 1: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Isoform 2: Has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers. This gene encodes a member of the glycosyl hydrolase 35 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature lysosomal enz ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307363
  • ENSP00000306920
  • ENSG00000170266
  • ENST00000399402
  • ENSP00000382333
  • ENST00000445488
  • ENSP00000393377

Symbol
  • ELNR1
  • EBP
  • ELNR1
  • MPS4B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
protein domain
0.85
disease perturbation
0.83
cellular component
0.79
histone modification site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 403.17   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 607   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 403.17   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 607   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (203)
C7orf43
Tdark
Novelty:  1.11975505
p_int:  0.999918072
p_ni:  0.000081927
Score:  0.768
Data Source:  BioPlex,STRINGDB
TRAPPC10
Tbio
Novelty:  0.03433058
p_int:  0.99987391
p_ni:  0.00012609
Score:  0.671
Data Source:  BioPlex,STRINGDB
TRAPPC9
Tbio
Novelty:  0.02703008
p_int:  0.999796941
p_ni:  0.000203059
Score:  0.534
Data Source:  BioPlex,STRINGDB
TRAPPC6B
Tbio
Novelty:  0.15086531
p_int:  0.999682239
p_ni:  0.000317751
p_wrong:  1e-8
Score:  0.735
Data Source:  BioPlex,STRINGDB
KLHDC9
Tbio
Novelty:  1.56875574
p_int:  0.997754741
p_ni:  0.002245259
Score:  0.161
Data Source:  BioPlex,STRINGDB
TRAPPC1
Tbio
Novelty:  0.09781468
p_int:  0.996735421
p_ni:  0.003264579
Score:  0.967
Data Source:  BioPlex,STRINGDB
TRAPPC4
Tbio
Novelty:  0.05749912
p_int:  0.993039326
p_ni:  0.006960669
p_wrong:  5e-9
Score:  0.671
Data Source:  BioPlex,STRINGDB
P10314
Tbio
Novelty:  0.00270731
p_int:  0.991728759
p_ni:  0.008271241
Data Source:  BioPlex
C9orf40
Tdark
Novelty:  2.72763898
p_int:  0.987273734
p_ni:  0.012726266
Data Source:  BioPlex
TRAPPC3
Tbio
Novelty:  0.0360262
p_int:  0.966443845
p_ni:  0.033556155
Score:  0.735
Data Source:  BioPlex,STRINGDB
Pathways (61)
Asparagine N-linked glycosylation (R-HSA-446203)

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Find Similar Targets
Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective NEU1 causes sialidosis
Reactome
Disease
Reactome
Diseases associated with glycosylation precursor biosynthesis
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective NEU1 causes sialidosis
Disease
Diseases associated with glycosylation precursor biosynthesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
4
5
95.4
eosinophil percentage of leukocytes
2
3
3
90.9
5
3
0
1.1
89.3
1
1
0
1.3
73.3
Eczema
2
2
0
1
71.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
95.4
eosinophil percentage of leukocytes
3
90.9
0
1.1
89.3
0
1.3
73.3
Eczema
0
1
71.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
galactosidase beta 1
VGNC:7062
460254
Mouse
MGI:88151
12091
Rat
RGD:1597145
316033
Dog
galactosidase beta 1
VGNC:41249
403873
Horse
galactosidase beta 1
VGNC:18367
100056330
Species
Name
OMA
EggNOG
Inparanoid
Chimp
galactosidase beta 1
Mouse
Rat
Dog
galactosidase beta 1
Horse
galactosidase beta 1
Publication Statistics
PubMed Score 403.17
PubMed score by year
PubTator Score 3752.75
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title