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Tbio
GK
Glycerol kinase

Protein Summary
Description
Key enzyme in the regulation of glycerol uptake and metabolism. The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378943
  • ENSP00000368226
  • ENSG00000198814
  • ENST00000378945
  • ENSP00000368228
  • ENST00000378946
  • ENSP00000368229
  • ENST00000427190
  • ENSP00000401720

Symbol
  • GK1
  • GKD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
cellular component
0.77
PubMedID
0.76
gene perturbation
0.75
transcription factor
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.77   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 304   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.77   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 304   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (141)
GK3P
Tdark
Family:  Kinase
p_int:  1
Data Source:  BioPlex
GK2
Tbio
Family:  Kinase
Novelty:  0.16461898
p_int:  0.999995109
p_ni:  3e-9
p_wrong:  0.000004888
Score:  0.807
Data Source:  BioPlex,STRINGDB
GHITM
Tbio
Novelty:  0.00360652
p_int:  0.999673331
p_ni:  0.000326669
Data Source:  BioPlex
SLC5A8
Tchem
Family:  Transporter
Novelty:  0.00892277
p_int:  0.985291546
p_ni:  0.014708453
Data Source:  BioPlex
SCGB1D2
Tbio
Novelty:  0.02178942
p_int:  0.979065681
p_ni:  0.015259927
p_wrong:  0.005674392
Data Source:  BioPlex
UBP1
Tbio
Family:  TF
Novelty:  0.01140885
p_int:  0.978727917
p_ni:  0.019273914
p_wrong:  0.001998169
Data Source:  BioPlex
HBB
Tbio
Novelty:  0.00049683
p_int:  0.976949427
p_ni:  0.023050573
Data Source:  BioPlex
DR1
Tbio
Novelty:  0.00138571
p_int:  0.974816626
p_ni:  0.025183374
Data Source:  BioPlex
CMTM8
Tbio
Novelty:  0.0953768
p_int:  0.970206158
p_ni:  0.029793842
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.964849312
p_ni:  0.035150688
Data Source:  BioPlex
Pathways (14)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Triglyceride biosynthesis
Reactome
Triglyceride metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Triglyceride biosynthesis
Triglyceride metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:106594
14933
Horse
glycerol kinase
100051016
Cow
glycerol kinase
505987
Pig
glycerol kinase
100233182
Chicken
glycerol kinase
CGNC:50798
418589
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
glycerol kinase
Cow
glycerol kinase
Pig
glycerol kinase
Chicken
glycerol kinase
Publication Statistics
PubMed Score 126.77
PubMed score by year
PubTator Score 71.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title