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Tdark
GJD4
Gap junction delta-4 protein

Protein Summary
Description
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Connexins, such as GJD4, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321660
  • ENSP00000315070
  • ENSG00000177291

Symbol
  • CX40.1
  • CX40.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.72
protein domain
0.58
cell type or tissue
0.51
cell line
0.42
chemical
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.84   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.84   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
FXYD4
Tdark
Family:  IC
Novelty:  0.11545177
Score:  0.931
Data Source:  STRINGDB
WDR49
Tdark
Novelty:  1.46160123
Score:  0.632
Data Source:  STRINGDB
NRSN2
Tbio
Novelty:  0.1812093
Score:  0.6
Data Source:  STRINGDB
ZBBX
Tdark
Novelty:  1.66474399
Score:  0.545
Data Source:  STRINGDB
FSTL5
Tbio
Novelty:  0.09979909
Score:  0.523
Data Source:  STRINGDB
GJA1
Tbio
Novelty:  0.00021332
Score:  0.485
Data Source:  STRINGDB
GJA5
Tbio
Novelty:  0.00195794
Score:  0.459
Data Source:  STRINGDB
GJD2
Tbio
Novelty:  0.00263903
Score:  0.457
Data Source:  STRINGDB
GJC1
Tbio
Novelty:  0.00375192
Score:  0.457
Data Source:  STRINGDB
PANX1
Tbio
Family:  IC
Novelty:  0.00159814
Score:  0.456
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Gap junction assembly (R-HSA-190861)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gap junction assembly
Reactome
Gap junction trafficking
Reactome
Gap junction trafficking and regulation
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Gap junction assembly
Gap junction trafficking
Gap junction trafficking and regulation
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gap junction protein delta 4
VGNC:5461
738077
Mouse
MGI:2444990
225152
Rat
RGD:628621
266707
Horse
gap junction protein delta 4 [Source:HGNC Symbol;Acc:HGNC:23296]
Cow
gap junction protein delta 4
VGNC:29386
522234
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gap junction protein delta 4
Mouse
Rat
Horse
gap junction protein delta 4 [Source:HGNC Symbol;Acc:HGNC:23296]
Cow
gap junction protein delta 4
Publication Statistics
PubMed Score 1.84
PubMed score by year
PubTator Score 1.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title