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Tbio
GJD3
Gap junction delta-3 protein

Protein Summary
Description
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. This gene is a member of the large family of connexins that are required for the formation of gap junctions. Six connexin monomers form a hemichannel, or connexon, on the cell surface. This connexon can interact with a connexon from a neighboring cell, thus forming a channel linking the cytoplasm of the 2 cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000578689
  • ENSP00000463752
  • ENSG00000183153

Symbol
  • GJA11
  • GJC1
  • GJC1
  • GJA11
  • CX31.9
  • Cx30.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
cell line
0.53
tissue sample
0.52
molecular function
0.49
transcription factor binding site profile
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.32   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.32   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
TJP1
Tbio
Novelty:  0.00040365
Score:  0.873
Data Source:  STRINGDB
GJB1
Tbio
Novelty:  0.00109019
Score:  0.757
Data Source:  STRINGDB
GJA5
Tbio
Novelty:  0.00195794
Score:  0.747
Data Source:  STRINGDB
GJB2
Tbio
Novelty:  0.00056398
Score:  0.739
Data Source:  STRINGDB
GJA8
Tbio
Novelty:  0.00377739
Score:  0.737
Data Source:  STRINGDB
GJE1
Tdark
Novelty:  0.03519662
Score:  0.713
Data Source:  STRINGDB
GJA1
Tbio
Novelty:  0.00021332
Score:  0.598
Data Source:  STRINGDB
GJC1
Tbio
Novelty:  0.00375192
Score:  0.592
Data Source:  STRINGDB
HCN4
Tclin
Family:  IC
Novelty:  0.0021957
Score:  0.584
Data Source:  STRINGDB
CDH2
Tbio
Novelty:  0.00040112
Score:  0.497
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Gap junction assembly (R-HSA-190861)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gap junction assembly
Reactome
Gap junction trafficking
Reactome
Gap junction trafficking and regulation
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Gap junction assembly
Gap junction trafficking
Gap junction trafficking and regulation
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
4
54.9
response to cetuximab
1
1
0
4
54.9
1
1
0
4
54.9
BMI-adjusted hip circumference
1
1
1
44.6
body height
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
4
54.9
response to cetuximab
0
4
54.9
0
4
54.9
BMI-adjusted hip circumference
1
44.6
body height
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gap junction protein delta 3
VGNC:12222
745773
Macaque
gap junction protein delta 3
700473
Mouse
MGI:2384150
353155
Rat
RGD:1308942
363677
Opossum
gap junction protein delta 3 [Source:HGNC Symbol;Acc:HGNC:19147]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gap junction protein delta 3
Macaque
gap junction protein delta 3
Mouse
Rat
Opossum
gap junction protein delta 3 [Source:HGNC Symbol;Acc:HGNC:19147]
Publication Statistics
PubMed Score 17.32
PubMed score by year
PubTator Score 4.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title