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Tbio
GJC1
Gap junction gamma-1 protein

Protein Summary
Description
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330514
  • ENSP00000333193
  • ENSG00000182963
  • ENST00000426548
  • ENSP00000411528
  • ENST00000590758
  • ENSP00000466339
  • ENST00000592524
  • ENSP00000467201

Symbol
  • GJA7
  • CX45
  • GJA7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.74
protein domain
0.73
PubMedID
0.71
transcription factor binding site profile
0.69
cellular component
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.46   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 319   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.46   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 319   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.999536135
p_ni:  0.000444543
p_wrong:  0.000019322
Data Source:  BioPlex
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.997211309
p_ni:  0.001241488
p_wrong:  0.001547203
Data Source:  BioPlex
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.996150244
p_ni:  0.00262846
p_wrong:  0.001221296
Data Source:  BioPlex
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
p_int:  0.996128368
p_ni:  0.00387162
p_wrong:  1.3e-8
Data Source:  BioPlex
PTGIR
Tclin
Family:  GPCR
Novelty:  0.0091906
p_int:  0.994496027
p_ni:  0.003795644
p_wrong:  0.001708328
Score:  0.164
Data Source:  BioPlex,STRINGDB
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.985522367
p_ni:  0.010001507
p_wrong:  0.004476126
Data Source:  BioPlex
SLC22A16
Tbio
Family:  Transporter
Novelty:  0.03379851
p_int:  0.984559274
p_ni:  0.013579756
p_wrong:  0.00186097
Data Source:  BioPlex
SLC18A1
Tchem
Family:  Transporter
Novelty:  0.01135292
p_int:  0.984271833
p_ni:  0.015215178
p_wrong:  0.000512989
Data Source:  BioPlex
EXTL2
Tbio
Family:  Enzyme
Novelty:  0.05051027
p_int:  0.965670989
p_ni:  0.024904105
p_wrong:  0.009424907
Score:  0.866
Data Source:  BioPlex,STRINGDB
ZACN
Tchem
Family:  IC
Novelty:  0.21891621
p_int:  0.938373443
p_ni:  0.058759353
p_wrong:  0.002867204
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Electric Transmission Across Gap Junctions (R-HSA-112303)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Electric Transmission Across Gap Junctions
Reactome
Gap junction assembly
Reactome
Gap junction trafficking
Reactome
Gap junction trafficking and regulation
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Electric Transmission Across Gap Junctions
Gap junction assembly
Gap junction trafficking
Gap junction trafficking and regulation
Membrane Trafficking
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
2
3
89.5
biological sex
1
1
1
49.5
cognitive function measurement
1
2
2
31.2
electrocardiography
1
1
1
29
self reported educational attainment
1
1
1
15.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
89.5
biological sex
1
49.5
cognitive function measurement
2
31.2
electrocardiography
1
29
self reported educational attainment
1
15.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
gap junction protein gamma 1
715463
Mouse
MGI:95718
14615
Rat
RGD:628889
266706
Dog
gap junction protein gamma 1
VGNC:41243
490936
Horse
gap junction protein gamma 1
VGNC:18360
100050732
Species
Name
OMA
EggNOG
Inparanoid
Macaque
gap junction protein gamma 1
Mouse
Rat
Dog
gap junction protein gamma 1
Horse
gap junction protein gamma 1
Publication Statistics
PubMed Score 235.46
PubMed score by year
PubTator Score 104.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title