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Tbio
GJB7
Gap junction beta-7 protein

Protein Summary
Description
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Connexins, such as GJB7, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000525899
  • ENSP00000435355
  • ENSG00000164411

Symbol
  • CX25
  • CX25
  • bA136M9.1
  • connexin25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.61
protein domain
0.58
cell type or tissue
0.44
chemical
0.41
tissue sample
0.39


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.1   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.1   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
UBTD1
Tdark
Novelty:  0.50393104
p_int:  0.99999994
p_wrong:  6e-8
Score:  0.235
Data Source:  BioPlex,STRINGDB
CCNY
Tbio
Novelty:  0.01400663
p_int:  0.99995727
p_ni:  0.000042726
p_wrong:  5e-9
Data Source:  BioPlex
GRTP1
Tdark
Novelty:  0.8841166
p_int:  0.999814898
p_ni:  0.000184991
p_wrong:  1.1e-7
Data Source:  BioPlex
CCNYL1
Tdark
Novelty:  0.45350824
p_int:  0.999804738
p_ni:  0.00019526
p_wrong:  2e-9
Data Source:  BioPlex
NRN1
Tbio
Novelty:  0.01198116
p_int:  0.999555327
p_ni:  0.000422299
p_wrong:  0.000022374
Data Source:  BioPlex
GNAZ
Tbio
Novelty:  0.02008523
p_int:  0.99887041
p_ni:  0.001129587
p_wrong:  3e-9
Data Source:  BioPlex
EFR3A
Tbio
Novelty:  0.17687362
p_int:  0.99825951
p_ni:  0.001740481
p_wrong:  8e-9
Data Source:  BioPlex
ERICH5
Tdark
Novelty:  5.57504212
p_int:  0.997521005
p_ni:  0.002478993
p_wrong:  2e-9
Data Source:  BioPlex
PAG1
Tbio
Novelty:  0.01390911
p_int:  0.997044075
p_ni:  0.002955924
p_wrong:  1e-9
Data Source:  BioPlex
ULBP2
Tbio
Novelty:  0.01604318
p_int:  0.996900437
p_ni:  0.003074426
p_wrong:  0.000025137
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Gap junction assembly (R-HSA-190861)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gap junction assembly
Reactome
Gap junction trafficking
Reactome
Gap junction trafficking and regulation
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Gap junction assembly
Gap junction trafficking
Gap junction trafficking and regulation
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
2
2
2
74.5
neutrophil count
2
2
2
74.1
lymphocyte percentage of leukocytes
2
2
2
70
eosinophil count
3
2
3
67.3
eosinophil percentage of leukocytes
1
1
1
66.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
2
74.5
neutrophil count
2
74.1
lymphocyte percentage of leukocytes
2
70
eosinophil count
3
67.3
eosinophil percentage of leukocytes
1
66.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Horse
gap junction protein beta 7
VGNC:51032
100070584
Opossum
gap junction protein beta 7
100025224
Xenopus
gap junction protein beta 7
XB-GENE-965093
100488401
Zebrafish
ZDB-GENE-050616-1
566668
Species
Name
OMA
EggNOG
Inparanoid
Horse
gap junction protein beta 7
Opossum
gap junction protein beta 7
Xenopus
gap junction protein beta 7
Zebrafish
Publication Statistics
PubMed Score 8.10
PubMed score by year
PubTator Score 3.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title