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Tbio
GJB6
Gap junction beta-6 protein

Protein Summary
Description
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241124
  • ENSP00000241124
  • ENSG00000121742
  • ENST00000356192
  • ENSP00000348521
  • ENST00000400065
  • ENSP00000382938
  • ENST00000400066
  • ENSP00000382939
  • ENST00000636852
  • ENSP00000489698
  • ENST00000643121
  • ENSP00000494468
  • ENST00000643211
  • ENSP00000495841
  • ENST00000644283
  • ENSP00000495320
  • ENST00000644667
  • ENSP00000493621
  • ENST00000647029
  • ENSP00000493834
  • ENST00000647243
  • ENSP00000494733

Symbol
  • ED2
  • EDH
  • HED
  • CX30
  • HED2
  • DFNA3
  • ECTD2
  • DFNA3B
  • DFNB1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
biological term
0.77
phenotype
0.68
disease
0.65
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 923.41   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 923.41   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
EDA
Tbio
Novelty:  0.00352464
Score:  0.92
Data Source:  STRINGDB
CNST
Tdark
Novelty:  0.10372637
Score:  0.785
Data Source:  STRINGDB
GJE1
Tdark
Novelty:  0.03519662
Score:  0.747
Data Source:  STRINGDB
GPR61
Tbio
Family:  GPCR
Novelty:  0.11649666
Score:  0.746
Data Source:  STRINGDB
PANX1
Tbio
Family:  IC
Novelty:  0.00159814
Score:  0.714
Data Source:  STRINGDB
PANX2
Tbio
Family:  IC
Novelty:  0.00620748
Score:  0.698
Data Source:  STRINGDB
PANX3
Tbio
Family:  IC
Novelty:  0.0071997
Score:  0.687
Data Source:  STRINGDB
SLC26A4
Tbio
Family:  Transporter
Novelty:  0.00162006
Score:  0.682
Data Source:  STRINGDB
MYO15A
Tbio
Novelty:  0.0148787
Score:  0.669
Data Source:  STRINGDB
TJP1
Tbio
Novelty:  0.00040365
Score:  0.668
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Gap junction assembly (R-HSA-190861)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gap junction assembly
Reactome
Gap junction trafficking
Reactome
Gap junction trafficking and regulation
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Gap junction assembly
Gap junction trafficking
Gap junction trafficking and regulation
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
12.4
14.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
12.4
14.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gap junction protein beta 6
VGNC:5062
750343
Macaque
gap junction protein beta 6
704105
Mouse
MGI:107588
14623
Rat
RGD:621830
84403
Dog
gap junction protein beta 6
VGNC:41242
100688824
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gap junction protein beta 6
Macaque
gap junction protein beta 6
Mouse
Rat
Dog
gap junction protein beta 6
Publication Statistics
PubMed Score 923.41
PubMed score by year
PubTator Score 326.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title