Tbio GJB5 Gap junction beta-5 protein

Protein Summary

Description

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. This gene encodes a member of the beta-type (group I) connexin family. The encoded protein is a gap junction protein involved in intercellular communication related to epidermal differentiation and environmental sensing. This gene has been linked to non-small cell lung cancer. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• O95377
• Q9UPA3

Gene Name

• GJB5

Ensembl ID

• ENST00000338513
• ENSP00000340811
• ENSG00000189280

Symbol

• CX31.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
gene perturbation	0.8
PubMedID	0.78
protein domain	0.73
transcription factor binding site profile	0.47

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Gap Junction / Gap Junction Beta-5 Protein

DTO Classes

Protein / Cell-cell Junction / Gap Junction / Gap Junction Beta-5 Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.26   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 149   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.26   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0